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Anti-ABCC1 antibody

[STJ22459] Download PDF Print Data Sheet

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Product name Anti-ABCC1 antibody
Short Description Rabbit Polyclonal against ABCC1 protein
Description The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
Applications IHC, WB
Dilution range WB 1:500-1:1000
IHC 1:50-1:100
Protein Name Multidrug resistance-associated protein 1
ATP-binding cassette sub-family C member 1
Leukotriene C
4 transporter
LTC4 transporter
Immunogen A synthetic peptide derived from human ABCC1.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification Anti-ABCC1 antibody was affinity purified using immunizing peptide
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Gene ID 4363
Gene Symbol ABCC1
Database Links HGNC:51
OMIM:158343
Alternative Names ABCC1 antibody
MRP antibody
MRP1 antibody
Multidrug resistance-associated protein 1 antibody
ATP-binding cassette sub-family C member 1 antibody
Leukotriene C antibody
4 transporter antibody
LTC4 transporter antibody
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs. Hydrolyzes ATP with low efficiency.
Cellular Localization Cell membrane
Tissue Specificity Lung, testis and peripheral blood mononuclear cells.

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Jian Yang, Paulina A. Samsel, Kalin Narov, Ashley Jones, Daniel Gallacher, John Gallacher, Julian R. Sampson, Ming Hong Shen. "Combination of Everolimus with Sorafenib for Solid Renal Tumors in Tsc2+/− Mice Is Superior to Everolimus Alone". Neoplasia Volume 19, Issue 2, February 2017, Pages 112–120. http://dx.doi.org/10.1016/j.neo.2016.12.008