• Western blot analysis of extracts of various cell lines, using MRP1/ABCC1 antibody (STJ22459) at 1:500 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
  • Western blot analysis of extracts of A-549 cells, using MRP1/ABCC1 antibody (STJ22459) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.

Anti-ABCC1 antibody (850-1531) (STJ22459)

SKU:
STJ22459

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Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-MRP1/ABCC1 (850-1531) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
IHC-P 1:50-1:200
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCC1
Gene ID: 4363
Uniprot ID: MRP1_HUMAN
Immunogen Region: 850-1531
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 850-1531 of human MRP1/ABCC1 (NP_004987.2).
Immunogen Sequence: GSYQELLARDGAFAEFLRTY ASTEQEQDAEENGVTGVSGP GKEAKQMENGMLVTDSAGKQ LQRQLSSSSSYSGDISRHHN STAELQKAEAKKEETWKLME ADKAQTGQVKL
Tissue Specificity Lung, testis and peripheral blood mononuclear cells.
Function Mediates export of organic anions and drugs from the cytoplasm. Mediates ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs and other xenobiotics. Confers resistance to anticancer drugs by decreasing accumulation of drug in cells, and by mediating ATP- and GSH-dependent drug export. Hydrolyzes ATP with low efficiency. Catalyzes the export of sphingosine 1-phosphate from mast cells independently of their degranulation. Participates in inflammatory response by allowing export of leukotriene C4 from leukotriene C4-synthezing cells. Mediates ATP-dependent, GSH-independent cyclic GMP-AMP (cGAMP) export. Thus, by limiting intracellular cGAMP concentrations negatively regulates the cGAS-STING pathway.
Protein Name Multidrug Resistance-Associated Protein 1
Atp-Binding Cassette Sub-Family C Member 1
Glutathione-S-Conjugate-Translocating Atpase Abcc1
Leukotriene C(4 Transporter
Ltc4 Transporter
Database Links Reactome: R-HSA-189483
Reactome: R-HSA-2142691
Reactome: R-HSA-382556
Reactome: R-HSA-9707564
Reactome: R-HSA-9753281
Reactome: R-HSA-9758890
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Multidrug Resistance-Associated Protein 1 antibody
Anti-Atp-Binding Cassette Sub-Family C Member 1 antibody
Anti-Glutathione-S-Conjugate-Translocating Atpase Abcc1 antibody
Anti-Leukotriene C(4 Transporter antibody
Anti-Ltc4 Transporter antibody
Anti-ABCC1 antibody
Anti-MRP antibody
Anti-MRP1 antibody

Information sourced from Uniprot.org

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