| Host: |
Mouse |
| Applications: |
WB/IF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Calnexin (EERPWLWVVYILTVAL) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
3H4A7 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2b |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CANX |
| Gene ID: |
821 |
| Uniprot ID: |
CALX_HUMAN |
| Immunogen Region: |
EERPWLWVVYILTVAL |
| Specificity: |
Calnexin Monoclonal Antibody detects endogenous levels of Calnexin protein. |
| Immunogen: |
Synthetic peptide corresponding to aa (CEthe amino acidEERPWLWVVYILTVAL) of human Calnexin, conjugated to KLH. |
| Function | Calcium-binding protein that interacts with newly synthesized monoglucosylated glycoproteins in the endoplasmic reticulum. It may act in assisting protein assembly and/or in the retention within the ER of unassembled protein subunits. It seems to play a major role in the quality control apparatus of the ER by the retention of incorrectly folded proteins. Associated with partial T-cell antigen receptor complexes that escape the ER of immature thymocytes, it may function as a signaling complex regulating thymocyte maturation. Additionally it may play a role in receptor-mediated endocytosis at the synapse. |
| Protein Name | CalnexinIp90Major Histocompatibility Complex Class I Antigen-Binding Protein P88P90 |
| Database Links | Reactome: R-HSA-168316Reactome: R-HSA-2132295Reactome: R-HSA-8984722Reactome: R-HSA-901042Reactome: R-HSA-9020956Reactome: R-HSA-9683686Reactome: R-HSA-9694548Reactome: R-HSA-983170 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinEndoplasmic ReticulumMelanosomeIdentified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage IvThe Palmitoylated Form Preferentially Localizes To The Perinuclear Rough Er |
| Alternative Antibody Names | Anti-Calnexin antibodyAnti-Ip90 antibodyAnti-Major Histocompatibility Complex Class I Antigen-Binding Protein P88 antibodyAnti-P90 antibodyAnti-CANX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
