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Anti-COX7A2L antibody

[STJ110597] Download PDF Print Data Sheet

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Product name Anti-COX7A2L antibody
Short Description Rabbit Polyclonal against COX7A2L protein
Description Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Cytochrome c oxidase subunit 7A-related protein, mitochondrial
COX7a-related protein
Cytochrome c oxidase subunit VIIa-related protein
Immunogen Recombinant peptide derived from human COX7A2L.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification Anti-COX7A2L antibody was affinity purified using immunizing peptide
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Gene ID 9167
Gene Symbol COX7A2L
Database Links HGNC:2289
Alternative Names COX7A2L antibody
COX7AR antibody
COX7RP antibody
Cytochrome c oxidase subunit 7A-related protein, mitochondrial antibody
COX7a-related protein antibody
Cytochrome c oxidase subunit VIIa-related protein antibody
EB1 antibody
Function Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).
Cellular Localization Mitochondrion inner membrane


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Sara Cogliati, Enrique Calvo, Marta Loureiro, Adela M. Guaras, Rocio Nieto-Arellano, Carolina Garcia-Poyatos, Iakes Ezkurdia, Nadia Mercader, Jesús Vázquez & José Antonio Enriquez. Mechanism of super-assembly of respiratory complexes III and IV. Nature 539, 579–582. Published online 24 October 2016. doi:10.1038/nature20157