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Anti-DSPP antibody

[STJ110711] Download PDF Print Data Sheet

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Product name Anti-DSPP antibody
Short Description Rabbit Polyclonal against DSPP protein
Description This gene encodes two principal proteins of the dentin extracellular matrix of the tooth. The preproprotein is secreted by odontoblasts and cleaved into dentin sialoprotein and dentin phosphoprotein. Dentin phosphoprotein is thought to be involved in the biomineralization process of dentin. Mutations in this gene have been associated with dentinogenesis imperfecta-1 / in some individuals, dentinogenesis imperfecta occurs in combination with an autosomal dominant form of deafness. Allelic differences due to repeat polymorphisms have been found for this gene.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name DSPP
Immunogen Recombinant peptide derived from human DSPP.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification Anti-DSPP antibody was affinity purified using immunizing peptide
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Gene Symbol DSPP
Alternative Names DSPP antibody
Function DSP may be an important factor in dentinogenesis. DPP may bind high amount of calcium and facilitate initial mineralization of dentin matrix collagen as well as regulate the size and shape of the crystals.
Post-translational Modifications DSP is glycosylated.
Cellular Localization Secreted, extracellular space, extracellular matrix.
Tissue Specificity Expressed in teeth. DPP is synthesized by odontoblast and transiently expressed by pre-ameloblasts.

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Ren J, Liang G, Gong L, Guo B, Jiang H. Rac1 Regulates the Proliferation, Adhesion, Migration, and Differentiation of MDPC-23 Cells. 16FEB2017. Regenerative Endodontics. http://dx.doi.org/10.1016/j.joen.2016.11.016