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Anti-FAAH antibody

[STJ23602] Download PDF Print Data Sheet

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Product name Anti-FAAH antibody
Short Description Rabbit Polyclonal against FAAH protein
Description Endogenous cannabinoids have been implicated in addictive behaviors and drug abuse (1). Fatty-acid amide hydrolase 1 (FAAH1) is a plasma membrane-bound hydrolase that converts oleamide to oleic acid (2). This hydrolase also converts the cannabinoid anandamide, the endogenous ligand for the CB1 cannabinoid receptor, to arachidonic acid, suggesting a role in fatty-acid amide inactivation (2). Mice lacking FAAH1 have significantly higher levels of anandamide in the brain and show decreased sensitivity to pain, further indicating a role for FAAH1 in the regulation of endocannabinoid signaling in vivo (3). FAAH1 null mice also demonstrate an increased preference for alcohol and an increased voluntary uptake of alcohol as compared to wild-type mice, indicating a role of FAAH1 in modulating addictive behaviors (1).
Applications WB
Dilution range WB 1:500-1:2000
IHC 1:50-1:200
Protein Name FAAH
Immunogen Recombinant peptide derived from human FAAH.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification Anti-FAAH antibody was affinity purified using immunizing peptide
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Gene Symbol FAAH
Alternative Names FAAH antibody
Function Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates.
Cellular Localization Endomembrane system Cytoplasm, cytoskeleton Note=Seems to be attached to intracellular membranes and a portion of the cytoskeletal network.
Tissue Specificity Highly expressed in the brain, small intestine, pancreas, skeletal muscle and testis. Also expressed in the kidney, liver, lung, placenta and prostate.

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Natalia Malek, Magdalena Kostrzewa, Wioletta Makuch,  Agnieszka Pajak, Mateusz Kucharczyk, Fabiana Piscitelli, Barbara Przewlocka, Vincenzo Di Marzo, Katarzyna Starowicz. "The multiplicity of spinal AA-5-HT anti-nociceptive action in a rat model of neuropathic pain". Pharmacological Research Volume 111, September 2016, Pages 251–263. http://dx.doi.org/10.1016/j.phrs.2016.06.012