SHOPPING BASKET: 0 item(s) - £0.00  

You have no items in your shopping cart.

Anti-Patched antibody

[STJ94963] Download PDF Print Data Sheet
5-7 days

* Required Fields

£0.00
Product name Anti-Patched antibody
Description Rabbit Polyclonal to Patched.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Specificity Patched Polyclonal Antibody detects endogenous levels of Patched protein.
Protein Name Protein patched homolog 1
PTC
PTC1
Immunogen Synthesized peptide derived from human Patched
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 5727
Gene Symbol PTCH1
Molecular Weight 160 kDa
Database Links HGNC:9585
OMIM:109400
Alternative Names PTCH1 antibody
PTCH antibody
Protein patched homolog 1 antibody
PTC antibody
PTC1 antibody
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Post-translational Modifications Glycosylation is necessary for SHH binding. ; In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation.
Cellular Localization Membrane; Multi-pass membrane protein.
Tissue Specificity In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.
Swiss-Prot Key Q13635_HUMAN
Bad Good
Enter the code in the box below:

Ask us a question

No questions yet. Be the first to ask the question!

Tags:

Use spaces to separate tags. Use single quotes (') for phrases.