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Anti-Phospho-14-3-3 β/ζ (S184/186) antibody

[STJ90562] Download PDF Print Data Sheet
Anti-Phospho-14-3-3 β/ζ (S184/186) antibody

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Product name Anti-Phospho-14-3-3 β/ζ (S184/186) antibody
Short Description Rabbit Polyclonal to Phospho-14-3-3 β/ζ (S184/186).
Description 14-3-3 β/ζ is a protein encoded by the YWHAZ gene which is approximately 27,7 kDa. 14-3-3 β/ζ is localised to the cytoplasm and melanosome. It is involved in the activation of cAMP-dependent PKA, development slit-robo signalling and activation of BH3-only proteins. It is an adapter protein implicated in the regulation of a large spectrum of both general and specialized signalling pathways. It binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. 14-3-3 β/ζ is expressed in the nervous system, intestine, skin, blood and eye. STJ90562 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous 14-3-3 β/ζ protein which only binds about S184/186 when S184/186 is phosphorylated.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:5000
Specificity Phospho-14-3-3 β/ζ (S184/186) Polyclonal Antibody detects endogenous levels of 14-3-3 β/ζ protein only when phosphorylated at S184/186.
Protein Name 14-3-3 protein zeta/delta
Protein kinase C inhibitor protein 1
KCIP-1
Immunogen Synthesized peptide derived from human 14-3-3 β/ζ around the phosphorylation site of S184/186.
Immunogen Region 120-200 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7534
Gene Symbol YWHAZ
Molecular Weight 28 kDa
Database Links HGNC:12855
OMIM:601288
Alternative Names YWHAZ antibody
14-3-3 protein zeta/delta antibody
Protein kinase C inhibitor protein 1 antibody
KCIP-1 antibody
Phospho-14-3-3 β/ζ (S184/186) antibody
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
Post-translational Modifications The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Thr-232; inhibits binding of RAF1. Phosphorylated on Ser-58 by PKA and protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53.
Cellular Localization Cytoplasm Melanosome Note=Located to stage I to stage IV melanosomes.

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