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Anti-Phospho-ErbB-3 (Y1197) antibody

[STJ90642] Download PDF Print Data Sheet

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Product name Anti-Phospho-ErbB-3 (Y1197) antibody
Short Description Rabbit Polyclonal to Phospho-ErbB-3 (Y1197).
Description ErbB-3 is a protein encoded by the ERBB3 gene which is approximately 148 kDa. ErbB-3 isoform 1 is localised to the cell membrane and isoform 2 is secreted. It is involved in RET signalling, GPCR pathway, GAB1 signalosome, signalling by ERBB2 and ERK signalling. The protein fall under the epidermal growth factor receptor family of receptor tyrosine kinases. It plays an essential role as a cell surface receptor for neuregulins. It binds to neuregulin-1 and is also activated by it. ErbB-3 is expressed in the brain and epithelial tissues. Mutations in the ERBB3 gene result in lethal congenital contracture syndrome. STJ90642 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous ErbB-3 protein which only binds about Y1197 when Y1197 is phosphorylated.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:40000
Specificity Phospho-ErbB-3 (Y1197) Polyclonal Antibody detects endogenous levels of ErbB-3 protein only when phosphorylated at Y1197.
Protein Name Receptor tyrosine-protein kinase erbB-3
Proto-oncogene-like protein c-ErbB-3
Tyrosine kinase-type cell surface receptor HER3
Immunogen Synthesized peptide derived from human ErbB-3 around the phosphorylation site of Y1197.
Immunogen Region 1140-1220 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 2065
Gene Symbol ERBB3
Molecular Weight 160-170 kDa
Database Links HGNC:3431
OMIM:190151
Alternative Names ERBB3 antibody
HER3 antibody
Receptor tyrosine-protein kinase erbB-3 antibody
Proto-oncogene-like protein c-ErbB-3 antibody
Tyrosine kinase-type cell surface receptor HER3 antibody
Phospho-ErbB-3 (Y1197) antibody
Function Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase . May also be activated by CSPG5 .
Post-translational Modifications Autophosphorylated . Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase .
Cellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein.; Isoform 2: Secreted.
Tissue Specificity Epithelial tissues and brain.
Sequence and Domain Family The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.

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