• Immunohistochemistry analysis of paraffin-embedded human brain, using Trk C (Phospho-Tyr516) Antibody. The picture on the right is blocked with the phospho peptide.
  • Western blot analysis of lysates from HeLa cells treated with serum 20% 15', using Trk C (Phospho-Tyr516) Antibody. The lane on the right is blocked with the phospho peptide.
  • Western blot analysis of HELA cells using Phospho-Trk C (Y516) Polyclonal Antibody

Anti-Phospho-NTRK3-Tyr516 antibody (482-531 aa) (STJ90960)

SKU:
STJ90960

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Phospho-NT-3 growth factor receptor-Tyr516 (482-531 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: NTRK3
Gene ID: 4916
Uniprot ID: NTRK3_HUMAN
Immunogen Region: 482-531 aa
Specificity: Phospho-Trk C (Y516) Polyclonal Antibody detects endogenous levels of Trk C protein only when phosphorylated at Y516.
Immunogen: The antiserum was produced against synthesized peptide derived from the human Trk C around the phosphorylation site of Tyr516 at the amino acid range 482-531
Post Translational Modifications Ligand-mediated auto-phosphorylation.
Function Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation.
Protein Name Nt-3 Growth Factor Receptor
Gp145-Trkc
Trk-C
Neurotrophic Tyrosine Kinase Receptor Type 3
Trkc Tyrosine Kinase
Database Links Reactome: R-HSA-388844
Reactome: R-HSA-9034013
Reactome: R-HSA-9034015
Reactome: R-HSA-9034793
Reactome: R-HSA-9034864
Reactome: R-HSA-9603381
Reactome: R-HSA-9603505
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Nt-3 Growth Factor Receptor antibody
Anti-Gp145-Trkc antibody
Anti-Trk-C antibody
Anti-Neurotrophic Tyrosine Kinase Receptor Type 3 antibody
Anti-Trkc Tyrosine Kinase antibody
Anti-NTRK3 antibody
Anti-TRKC antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance