SHOPPING BASKET: 0 item(s) - £0.00  

You have no items in your shopping cart.

Anti-POMC antibody

[STJ25054] Download PDF Print Data Sheet

* Required Fields

£0.00
Product name Anti-POMC antibody
Short Description Rabbit Polyclonal against POMC protein
Description This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used / adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation.
Applications WB
Dilution range WB 1:500-1:2000
Protein Name Pro-opiomelanocortin
POMC
Corticotropin-lipotropin
NPP
Melanotropin gamma
Gamma-MSH
Potential peptide
Corticotropin
Adrenocorticotropic hormone
ACTH
Melanocyte-stimulating hormone alpha
Alpha-MSH
Melanotropi
Immunogen Recombinant peptide derived from human POMC.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification Anti-POMC antibody was affinity purified using immunizing peptide
Isotype IgG
Formulation PBS with 0.02% sodium azide, 50% glycerol, pH7.4
Gene ID 5443
Gene Symbol POMC
Database Links HGNC:9201
OMIM:176830
Alternative Names POMC antibody
Pro-opiomelanocortin antibody
POMC antibody
Corticotropin-lipotropin antibody
NPP antibody
Melanotropin gamma antibody
Gamma-MSH antibody
Potential peptide antibody
Corticotropin antibody
Adrenocorticotropic hormone antibody
ACTH antibody
Melanocyte-stimulating hormone alpha antibody
Alpha-MSH antibody
Melanotropin alpha antibody
Corticotropin-like intermediary peptide antibody
CLIP antibody
Lipotropin beta antibody
Beta-LPH antibody
Lipotropin gamma antibody
Gamma-LPH antibody
Melanocyte-stimulating hormone beta antibody
Beta-MSH antibody
Melanotropin beta antibody
Beta-endorphin antibody
Met-enkephalin antibody
Function ACTH stimulates the adrenal glands to release cortisol.; MSH (melanocyte-stimulating hormone) increases the pigmentation of skin by increasing melanin production in melanocytes.; Beta-endorphin and Met-enkephalin are endogenous opiates.
Post-translational Modifications Specific enzymatic cleavages at paired basic residues yield the different active peptides. ; O-glycosylated; reducing sugar is probably N-acetylgalactosamine.
Cellular Localization Secreted.
Tissue Specificity ACTH and MSH are produced by the pituitary gland.

Tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Bad Good
Enter the code in the box below:
Li C-W, Pan W-T, Ju J-C, Wang G-J. An endothelial cultured condition medium embedded porous PLGA scaffold for the enhancement of mouse embryonic stem cell differentiation. Biomedical Materials. 11 (2016) 025015. doi:10.1088/1748-Biomed. Mater. 11 (2016) 025015 6041/11/2/025015