| Host: |
Mouse |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-Zinc finger and BTB domain-containing protein 7B is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
7C12 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
Liquid in PBS containing 0.03% Sodium Azide, 0.5% BSA, 50% Glycerol. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC 1:200-1:1000IF 1:200-1:1000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ZBTB7B |
| Gene ID: |
51043 |
| Uniprot ID: |
ZBT7B_HUMAN |
| Specificity: |
TH-POK Monoclonal Antibody detects endogenous levels of TH-POK protein. |
| Immunogen: |
Purified recombinant fragment of human TH-POK expressed in E. Coli. |
| Function | Transcription regulator that acts as a key regulator of lineage commitment of immature T-cell precursors. Exerts distinct biological functions in the mammary epithelial cells and T cells in a tissue-specific manner. Necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. Cross-antagonism between ZBTB7B and CBF complexes are determinative to CD4 versus CD8 cell fate decision. Suppresses RUNX3 expression and imposes CD4+ lineage fate by inducing the SOCS suppressors of cytokine signaling. induces, as a transcriptional activator, SOCS genes expression which represses RUNX3 expression and promotes the CD4+ lineage fate. During CD4 lineage commitment, associates with multiple sites at the CD8 locus, acting as a negative regulator of the CD8 promoter and enhancers by epigenetic silencing through the recruitment of class II histone deacetylases, such as HDAC4 and HDAC5, to these loci. Regulates the development of IL17-producing CD1d-restricted naural killer (NK) T cells. Also functions as an important metabolic regulator in the lactating mammary glands. Critical feed-forward regulator of insulin signaling in mammary gland lactation, directly regulates expression of insulin receptor substrate-1 (IRS-1) and insulin-induced Akt-mTOR-SREBP signaling. Transcriptional repressor of the collagen COL1A1 and COL1A2 genes. May also function as a repressor of fibronectin and possibly other extracellular matrix genes. Potent driver of brown fat development, thermogenesis and cold-induced beige fat formation. Recruits the brown fat lncRNA 1 (Blnc1):HNRNPU ribonucleoprotein complex to activate thermogenic gene expression in brown and beige adipocytes. |
| Protein Name | Zinc Finger And Btb Domain-Containing Protein 7bKrueppel-Related Zinc Finger Protein CkroxHckroxT-Helper-Inducing Poz/Krueppel-Like FactorZinc Finger And Btb Domain-Containing Protein 15Zinc Finger Protein 67 HomologZfp-67Zinc Finger Protein 857bZinc Finger Protein Th-Pok |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Zinc Finger And Btb Domain-Containing Protein 7b antibodyAnti-Krueppel-Related Zinc Finger Protein Ckrox antibodyAnti-Hckrox antibodyAnti-T-Helper-Inducing Poz/Krueppel-Like Factor antibodyAnti-Zinc Finger And Btb Domain-Containing Protein 15 antibodyAnti-Zinc Finger Protein 67 Homolog antibodyAnti-Zfp-67 antibodyAnti-Zinc Finger Protein 857b antibodyAnti-Zinc Finger Protein Th-Pok antibodyAnti-ZBTB7B antibodyAnti-ZBTB15 antibodyAnti-ZFP67 antibodyAnti-ZNF857B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
