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Anti-ADAM10 antibody

[STJ90014] Download PDF Print Data Sheet

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Product name Anti-ADAM10 antibody
Short Description Rabbit Polyclonal to ADAM10.
Description Rabbit Polyclonal to ADAM10.
Applications ELISA, WB
Dilution range WB 1:500-1:2000 / ELISA 1:20000 /
Specificity ADAM10 Polyclonal Antibody detects endogenous levels of ADAM10 protein.
Protein Name Disintegrin and metalloproteinase domain-containing protein 10 - ADAM10 - kuz - MADM - HsT18717 - CD156c - ADAM metallopeptidase domain 10
Immunogen Synthesized peptide derived from human ADAM10
Immunogen Region 170-250 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 102 (Human) /
Gene Symbol ADAM10
Molecular Weight 70 kDa
Database Links Human UniProt/Swiss-Prot:O14672 Mouse UniPort/Swiss-Prot: O35598 Rat UniProt/Swiss-Port: A0A0G2K562 Human Entrez Gene: 102 Mouse Entrez Gene: 11487 Rat Entrez Gene: Rn.42924
Alternative Names ADAM10 / ADAM metallopeptidase domain 10 / ad10 antibody / AD18 antibody / ADAM 10 antibody / ADAM-10 antibody / ADAM10 metallopeptidase antibody / a disintegrin and metallopeptidase domain 10 antibody / a disintegrin and metalloprotease domain 10 antibody / a disintegrin and metalloprotease domain (ADAM) 10 antibody / a disintegrin and metalloproteinase domain 10 antibody / AS27_14911 antibody / AS28_04210 antibody / cd156c antibody / CDw156 antibody / D623_10007056 antibody / disintegrin and metalloproteinase domain-containing protein 10 antibody / disintegrin metalloproteinase antibody / disintegrin-metalloproteinase antibody / H920_12604 antibody / HsT18717 antibody / I79_000174 antibody / kuz antibody / kuzbanian antibody / kuzbanian protein homolog antibody / M91_14882 antibody / M959_05263 antibody / MADM antibody / mammalian disintegrin-metalloprotease antibody / MDA_GLEAN10012027 antibody / metalloprotease /disintegrin antibody / myelin-associated metalloproteinase antibody / N300_11933 antibody / N301_08226 antibody / N302_04904 antibody / N303_08267 antibody / N305_08052 antibody / N306_09275 antibody / N307_06519 antibody / N308_02776 antibody / N309_04871 antibody / N310_09129 antibody / N311_12861 antibody / N312_09131 antibody / N320_10900 antibody / N322_11802 antibody / N324_04991 antibody / N326_04726 antibody / N327_08543 antibody / N328_05139 antibody / N329_10761 antibody / N330_02319 antibody / N331_11544 antibody / N332_13138 antibody / N333_07556 antibody / N335_13084 antibody / N336_10521 antibody / N339_07787 antibody / N340_10673 antibody / N341_05850 antibody / PAL_GLEAN10023430 antibody / PANDA_019470 antibody / RAK antibody / RGD1566370 antibody / TREES_T100000225 antibody / UY3_03823 antibody / xadam10 antibody / xKuz antibody / Y1Q_013892 antibody / Y956_05560 antibody / Z169_06651 antibody
Function Cleaves the membrane-bound precursor of TNF-alpha at '76-Ala-|-Val-77' to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface . Responsible for the proteolytic release of several other cell-surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) . Contributes to the normal cleavage of the cellular prion protein . Involved in the cleavage of the adhesion molecule L1 at the cell surface and in released membrane vesicles, suggesting a vesicle-based protease activity . Controls also the proteolytic processing of Notch and mediates lateral inhibition during neurogenesis (By similarity). Responsible for the FasL ectodomain shedding and for the generation of the remnant ADAM10-processed FasL (FasL APL) transmembrane form . Also cleaves the ectodomain of the integral membrane proteins CORIN and ITM2B . May regulate the EFNA5-EPHA3 signaling .
Post-translational Modifications The precursor is cleaved by a furin endopeptidase.
Cellular Localization Cell membrane Golgi apparatus membrane Note=Is localized in the plasma membrane but is predominantly expressed in the Golgi apparatus and in released membrane vesicles derived likely from the Golgi.
Tissue Specificity Expressed in spleen, lymph node, thymus, peripheral blood leukocyte, bone marrow, cartilage, chondrocytes and fetal liver.
Sequence and Domain Family The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.; The Cys-rich region C-terminal to the disintegrin domain functions as a substrate-recognition module, it recognizes the EFNA5-EPHA3 Complex but not the individual proteins (By similarity). Both Cys-rich and stalk region are necessary for interaction with TSPAN5, TSPAN10, TSPAN14, TSPAN17, TSPAN33 . Stalk region is sufficient for interaction with TSPAN15 (By similarity).


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