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Anti-α-Skeletal Muscle Actin antibody

[STJ97121] Download PDF Print Data Sheet

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Product name Anti-α-Skeletal Muscle Actin antibody
Short Description Rabbit Polyclonal to α-Skeletal Muscle Actin.
Description Rabbit Polyclonal to α-Skeletal Muscle Actin.
Applications WB
Dilution range WB 1:1000-2000
Specificity The antibody detects endogenousα Skeletal Muscle Actin protein.
Protein Name Actin alpha skeletal muscle - ACTA1 - NEM3 - ACTA - actin - alpha 1 - skeletal muscle
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 58 (Human) / 11459 (Mouse) / 29437 (Rat)
Gene Symbol ACTA1
Database Links Human UniProt/Swiss-Prot:P68133 Mouse UniPort/Swiss-Prot: P68134 Rat UniProt/Swiss-Port: P68136 Human Entrez Gene: 58 Mouse Entrez Gene: 11459 Rat Entrez Gene: Rn.82732
Alternative Names ACTA1 / actin / alpha 1 / skeletal muscle / A306_05440 antibody / a-actin antibody / acta antibody / acta2 antibody / Acta-2 antibody / ACTC1 antibody / actin alpha 1 antibody / actin / alpha 2 / smooth muscle / aorta antibody / actin / alpha / cardiac muscle 1 antibody / actin / alpha skeletal muscle antibody / actin / cytoplasmic 1 antibody / Actin / muscle antibody / Actin / muscle 2 /4 /4A antibody / Acts antibody / Actsk-1 antibody / alpha 1 skeletal muscle actin antibody / alpha-actin antibody / alpha actin 1 antibody / alpha-actin-1 antibody / Anapl_05254 antibody / AS27_01478 antibody / AS28_14001 antibody / asma antibody / beta actin antibody / CB1_000692045 antibody / CFTD antibody / cftd1 antibody / CFTDM antibody / cytoplasmic beta-actin antibody / I79_002310 antibody / M959_14679 antibody / MDA_GLEAN10009985 antibody / mpfd antibody / muscle actin OlMA1 antibody / N300_11475 antibody / N302_14497 antibody / N303_13384 antibody / N305_10725 antibody / N307_03431 antibody / N308_14129 antibody / N309_08916 antibody / N310_06384 antibody / NEM1 antibody / NEM2 antibody / NEM3 antibody / nemaline myopathy type 3 antibody / olMA1 antibody / SHPM antibody / skeletal alpha actin antibody / skeletal muscle alpha-actin 1 antibody / TREES_T100013855 antibody / UY3_17810 antibody / Y1Q_000635 antibody / Y956_02939 antibody / Z169_01146 antibody
Function Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.
Post-translational Modifications Oxidation of Met-46 and Met-49 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promote actin repolymerization (By similarity). ; Monomethylation at Lys-86 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. ; (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-52 of one monomer and Glu-272 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding . The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners .
Cellular Localization Cytoplasm, cytoskeleton.


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