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Anti-ApoE antibody

[STJ91638] Download PDF Print Data Sheet
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Product name Anti-ApoE antibody
Short Description Rabbit polyclonal to ApoE.
Description ApoE is a protein encoded by the APOE gene which is approximately 36,1 kDa. ApoE is secreted and is involved in lipoprotein metabolism, the statin pathway, respiratory electron transport and glucose / energy metabolism. It is a major apoprotein of chylomicrons. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. ApoE is expressed in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle. Mutations in the APOE gene may result in hyperlipoproteinemian. STJ91638 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of ApoE protein.
Applications ELISA, ICC, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:10000
Specificity ApoE Polyclonal Antibody detects endogenous levels of ApoE protein.
Protein Name Apolipoprotein E
Apo-E
Immunogen Synthesized peptide derived from human ApoE.
Immunogen Region Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 348
Gene Symbol APOE
Molecular Weight 36 kDa
Database Links HGNC:613
OMIM:104310
Alternative Names Anti-ApoE antibody
Function Mediates the binding, internalization, and catabolism of lipoprotein particles. It can serve as a ligand for the LDL (apo B/E) receptor and for the specific apo-E receptor (chylomicron remnant) of hepatic tissues.
Post-translational Modifications Synthesized with the sialic acid attached by O-glycosidic linkage and is subsequently desialylated in plasma. O-glycosylated with core 1 or possibly core 8 glycans. Thr-307 and Ser-314 are minor glycosylation sites compared to Ser-308. Glycated in plasma VLDL of normal subjects, and of hyperglycemic diabetic patients at a higher level (2-3 fold).; Phosphorylated by FAM20C in the extracellular medium.
Cellular Localization Secreted
Tissue Specificity Occurs in all lipoprotein fractions in plasma. It constitutes 10-20% of very low density lipoproteins (VLDL) and 1-2% of high density lipoproteins (HDL). APOE is produced in most organs. Significant quantities are produced in liver, brain, spleen, lung, adrenal, ovary, kidney and muscle.
Swiss-Prot Key P02649_HUMAN
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