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Anti-AR-β3 antibody

[STJ91728] Download PDF Print Data Sheet

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Product name Anti-AR-β3 antibody
Short Description Rabbit Polyclonal to AR-β3.
Description AR-β3 is a protein encoded by the ADRB3 gene which is approximately 43,5 kDa. AR-β3 is localised to the cell membrane. It is involved in peptide ligand-binding receptors, activation of cAMP-dependent PKA, signalling by GPCR and DAG and IP3 signalling. It mediates catecholamine-induced activation of adenylate cyclase through the action of G proteins and is involved in the regulation of lipolysis and thermogenesis. AR-β3 is expressed mainly in adipose tissue. Mutations in the ADRB3 gene may be involved in diabetes mellitus and obesity. STJ91728 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of AR-β3 protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000 / ELISA 1:20000 /
Specificity AR-β3 Polyclonal Antibody detects endogenous levels of AR-β3 protein.
Protein Name Beta-3 adrenergic receptor - ADRB3 - adrenoceptor beta 3
Immunogen Synthesized peptide derived from human AR-β3
Immunogen Region 220-300 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 155 (Human) / 11556 (Mouse) / 25645 (Rat)
Gene Symbol ADRB3
Molecular Weight 36 kDa
Database Links Human UniProt/Swiss-Prot:P13945 Mouse UniPort/Swiss-Prot: P25962 Rat UniProt/Swiss-Port: P26255 Human Entrez Gene: 155 Mouse Entrez Gene: 11556 Rat Entrez Gene: Rn.10100
Alternative Names ADRB3 / adrenoceptor beta 3 / A306_10648 antibody / ADRB antibody / ADRB1 antibody / Adrb-3 antibody / ADRB4C antibody / adrenergic / beta-1- / receptor antibody / adrenergic / beta 3 / receptor antibody / adrenergic / beta-3- / receptor antibody / adrenergic receptor beta 3 antibody / adrenergic receptor beta-3 antibody / adrenergic receptor / beta 3 antibody / adrenoceptor beta 1 antibody / AS27_08355 antibody / AS28_11702 antibody / B3AR antibody / BAR3 antibody / beta 3 adrenergic receptor antibody / beta 3-adrenergic receptor antibody / beta-3 adrenergic receptor antibody / beta-3-adrenergic receptor antibody / beta3 adrenergic receptor antibody / beta3-adrenergic receptor antibody / beta-3 adrenoceptor antibody / beta3-adrenoceptor antibody / Beta-3 adrenoreceptor antibody / beta 3-AR antibody / Beta-3 AR antibody / BETA3AR antibody / beta-4C-adrenergic receptor antibody / Beta-4C adrenergic receptor antibody / beta-4C adrenergic receptor-like antibody / beta-4C adrenergic receptor-like protein antibody / beta-4C adrenoceptor antibody / beta-4C adrenoreceptor antibody / CB1_000667026 antibody / Ferritin light chain antibody / GPCR antibody / hypothetical protein antibody / M91_06457 antibody / M959_07314 antibody / N303_05428 antibody / Nucleoplasmin antibody / PAL_GLEAN10021575 antibody / PANDA_005484 antibody / Y1Q_031046 antibody / Z169_06990 antibody
Function Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.
Cellular Localization Cell membrane; Multi-pass membrane protein.
Tissue Specificity Expressed mainly in adipose tissues.

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