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Anti-β I tubulin antibody

[STJ96939] Download PDF Print Data Sheet

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Product name Anti-β I tubulin antibody
Short Description Mouse Monoclonal to β I tubulin.
Description β I tubulin is a protein encoded by the TUBB1 gene which is approximately 50,3 kDa. β I tubulin is localised to the cytoplasm. It is involved in development Slit-Robo signalling, Sertoli-Sertoli cell junction dynamics, signalling in gap junctions and chaperonin-mediated protein folding. This protein falls under the beta tubulin protein family. It is one of two core protein families that heterodimerize and assemble to form microtubules. It is exists in platelets and megakaryocytes and may be involved in proplatelet production and platelet release. β I tubulin is expressed in the blood and cells of the nervous system. Mutations in the TUBB1 gene may result in macrothrombocytopaenia. STJ96939 was developed from clone 3F7 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous β I tubulin proteins.
Applications WB
Dilution range WB 1:5000-10000
Specificity The antibody detects endgenousβ I tubulin proteins.
Protein Name Tubulin beta-1 chain - TUBB1 - dJ543J19.4 - tubulin beta 1 class VI
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 3F7
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 81027 (Human) / 545486 (Mouse) /
Gene Symbol TUBB1
Database Links Human UniProt/Swiss-Prot:Q9H4B7 Mouse UniPort/Swiss-Prot: A2AQ07 Rat UniProt/Swiss-Port: M0R8B6 Human Entrez Gene: 81027 Mouse Entrez Gene: 545486
Alternative Names TUBB1 / tubulin beta 1 class VI / AS27_00621 antibody / AS28_06995 antibody / beta-tubulin class-VI antibody / CB1_000308004 antibody / EGK_02245 antibody / GW7_08855 antibody / M959_06518 antibody / M(beta)1 antibody / MDA_GLEAN10010087 antibody / N300_15728 antibody / N301_06262 antibody / N302_00382 antibody / N303_11140 antibody / N305_13208 antibody / N306_01713 antibody / N307_09850 antibody / N308_00077 antibody / N309_10078 antibody / N310_06867 antibody / N312_04818 antibody / N322_04115 antibody / N325_10839 antibody / N326_09641 antibody / N328_08214 antibody / N330_05777 antibody / N332_09496 antibody / N333_10278 antibody / N341_10291 antibody / PAL_GLEAN10024597 antibody / TREES_T100015628 antibody / TUBB3 antibody / TUBB4B antibody / tubulin beta-1 chain antibody / tubulin / beta 1 class VI antibody / tubulin / beta 3 antibody / tubulin / beta 4B class IVb antibody / Tubulin beta-6 chain antibody / tubulin / beta family 1 antibody / Y1Q_001274 antibody / Y956_12334 antibody / Z169_02770 antibody
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Post-translational Modifications Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group . Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold . ; Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable). ; Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
Cellular Localization Cytoplasm, cytoskeleton
Tissue Specificity Hematopoietic cell-specific. Major isotype in leukocytes, where it represents 50% of all beta-tubulins.


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