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Anti-β II Tubulin antibody

[STJ97122] Download PDF Print Data Sheet

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Product name Anti-β II Tubulin antibody
Short Description Rabbit Polyclonal to β II Tubulin.
Description Rabbit Polyclonal to β II Tubulin.
Applications WB
Dilution range WB 1:2000-5000
Specificity The antibody detects endogenous β II tubulin protein.
Protein Name Tubulin beta-2A chain - TUBB2A - dJ40E16.7 - TUBB - TUBB2 - tubulin beta 2A class IIa
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 7280 (Human) / 22151 (Mouse) / 498736 (Rat)
Gene Symbol TUBB2A
Database Links Human UniProt/Swiss-Prot:Q13885 Mouse UniPort/Swiss-Prot: Q7TMM9 Rat UniProt/Swiss-Port: P85108 Human Entrez Gene: 7280 Mouse Entrez Gene: 22151 Rat Entrez Gene: Rn.225893
Alternative Names TUBB2A / tubulin beta 2A class IIa / beta tubulin 2b antibody / CDCBM5 antibody / class IIa beta-tubulin antibody / M(beta)2 antibody / TUBB antibody / Tubb2 antibody / Tubb2b antibody / tubulin / beta 2A class IIa antibody / tubulin / beta 2B class IIb antibody / tubulin / beta polypeptide antibody / tubulin / beta polypeptide 2 antibody
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Post-translational Modifications Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group . Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold . ; Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable). ; Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
Cellular Localization Cytoplasm, cytoskeleton
Tissue Specificity High expression in brain, where it represents 30% of all beta-tubulins.

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