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Anti-β III Tubulin antibody

[STJ97123] Download PDF Print Data Sheet

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Product name Anti-β III Tubulin antibody
Short Description Rabbit Polyclonal to β III Tubulin.
Description Beta III tubulin is a protein encoded by the tubb3 gene which is approximately 50,4 kDa. Beta III tubulin is localised to the cytoplasm and cytoskeleton. It is involved in signalling within gap junctions, development slit-robo signalling, sertoli-sertoli cell junction dynamics, chaperonin-mediated protein folding and tubulin folding. This protein falls under the one of two protein families, namely beta and alpha tubulin and is one of six beta tubulin isoforms. Beta III tubulin is expressed in the neurons of the peripheral and central nervous system and plays an important role in guidance and maintenance and axons. Mutations in the tubb3 gene result in congenital fibrosis of extraocular muscles type. STJ97123 was developed from clone Mix. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous beta III tubulin protein.
Applications ICC, IF, WB
Dilution range WB 1:2000-5000
Specificity The antibody detects endogenous β III tubulin protein.
Protein Name Tubulin beta-3 chain - TUBB3 - beta-4 - CFEOM3 - CFEOM3A - FEOM3 - tubulin beta 3 class III
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 10381 (Human) / 22152 (Mouse) / 246118 (Rat)
Gene Symbol TUBB3
Database Links Human UniProt/Swiss-Prot:Q13509 Mouse UniPort/Swiss-Prot: Q9ERD7 Rat UniProt/Swiss-Port: Q4QRB4 Human Entrez Gene: 10381 Mouse Entrez Gene: 22152 Rat Entrez Gene: Rn.43958
Alternative Names TUBB3 / tubulin beta 3 class III / A306_01682 antibody / AS27_07488 antibody / beta-4 antibody / beta-4-tubulin antibody / betaIII-tubulin antibody / beta-tubulin class-III antibody / CDCBM antibody / CDCBM1 antibody / CFEOM3 antibody / CFEOM3A antibody / class III beta-tubulin antibody / D623_10003790 antibody / FEOM3 antibody / GW7_12416 antibody / H920_06773 antibody / hypothetical protein antibody / I79_000194 antibody / M(beta)3 antibody / M(beta)6 antibody / MC1R antibody / melanocortin 1 receptor antibody / melanocortin-1 receptor antibody / Melanocyte-stimulating hormone receptor antibody / N300_09138 antibody / N301_08954 antibody / N302_09664 antibody / N303_10590 antibody / N305_04768 antibody / N308_02301 antibody / neuron-specific class III beta-tubulin antibody / PANDA_016558 antibody / QccE-15186 antibody / TREES_T100001682 antibody / TUBB4 antibody / tubulin beta3 antibody / tubulin / beta / 3 antibody / Tubulin beta-3 chain antibody / tubulin / beta 3 class III antibody / tubulin / beta / 4 antibody / Tubulin beta-4 chain antibody / tubulin beta-III antibody / UY3_00776 antibody / Y956_10968 antibody
Function Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance.
Post-translational Modifications Some glutamate residues at the C-terminus are polyglutamylated, resulting in polyglutamate chains on the gamma-carboxyl group . Polyglutamylation plays a key role in microtubule severing by spastin (SPAST). SPAST preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity by SPAST increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold . ; Some glutamate residues at the C-terminus are monoglycylated but not polyglycylated due to the absence of functional TTLL10 in human. Monoglycylation is mainly limited to tubulin incorporated into axonemes (cilia and flagella). Both polyglutamylation and monoglycylation can coexist on the same protein on adjacent residues, and lowering glycylation levels increases polyglutamylation, and reciprocally. The precise function of monoglycylation is still unclear (Probable). ; Phosphorylated on Ser-172 by CDK1 during the cell cycle, from metaphase to telophase, but not in interphase. This phosphorylation inhibits tubulin incorporation into microtubules.
Cellular Localization Cytoplasm, cytoskeleton.
Tissue Specificity Expression is primarily restricted to central and peripheral nervous system. Greatly increased expression in most cancerous tissues.
Sequence and Domain Family The highly acidic C-terminal region may bind cations such as calcium.


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