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Anti-Caspase 9 antibody

[STJ96979] Download PDF Print Data Sheet

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Product name Anti-Caspase 9 antibody
Short Description Mouse Monoclonal to Caspase 9.
Description Caspase-9 is a protein encoded by the CASP9 gene which is approximately 46,2 kDa. Caspase-9 is localised to the cytosol, mitochondrion and nucleus. It is involved in the TNFR1 pathway, RET signalling and apoptosis modulation and signalling. Caspase-9 exist as an inactive proenzyme which undergoes proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. It is involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Caspase-9 is ubiquitously expressed with highest expression in the heart. Mutations in the CASP9 gene may result in cerebral hypoxia and cervical cancer. STJ96979 was affinity purified. This monoclonal antibody binds endogenous caspase-9.
Applications IP, WB
Dilution range WB 1:1000-5000 / IP 1:200
Specificity The antibody detects endogenous Caspase 9 protein.
Protein Name Caspase-9 - CASP9 - MCH6 - ICE-LAP6 - APAF-3 - PPP1R56 - caspase 9
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 3-20
Reactivity Chicken, Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 842 (Human) /
Gene Symbol CASP9
Database Links Human UniProt/Swiss-Prot:P55211 Mouse UniPort/Swiss-Prot: Q8C3Q9 Rat UniProt/Swiss-Port: Q9JHK1 Human Entrez Gene: 842 Mouse Entrez Gene: 12371 Rat Entrez Gene: Rn.32199
Alternative Names CASP9 / caspase 9 / 25 kDa caspase-9 dominant negative protein antibody / A306_07035 antibody / Apaf3 antibody / APAF-3 antibody / apoptosis-related cysteine peptidase Casp9 antibody / apoptosis-related cysteine peptidase caspase 9 antibody / apoptotic protease activating factor 3 antibody / apoptotic protease-activating factor 3 antibody / apoptotic protease Mch-6 antibody / AS27_12949 antibody / CASP-9 antibody / casp9-A antibody / Casp-9-CTD antibody / Casp9_v1 antibody / caspase9 antibody / Caspase-9 antibody / caspase 9 / apoptosis-related cysteine peptidase antibody / caspase 9 / apoptosis-related cysteine protease antibody / caspase-9c antibody / caspase-9-carboxyl-terminal divergent antibody / caspase-9 dominant negative form antibody / caspase-9 isoform alpha preproprotein antibody / CB1_001086005 antibody / H920_17855 antibody / hypothetical protein antibody / iCasp9 antibody / Ice-Lap6 antibody / Ice-like apoptotic protease 6 antibody / M91_10958 antibody / M959_03272 antibody / mch6 antibody / MDA_GLEAN10024334 antibody / N300_01463 antibody / N302_12235 antibody / N303_02623 antibody / N305_00851 antibody / N306_07560 antibody / N307_01404 antibody / N308_14775 antibody / N310_04426 antibody / N311_02867 antibody / N312_05430 antibody / N320_07326 antibody / N325_04188 antibody / N326_05445 antibody / N327_06932 antibody / N328_02780 antibody / N329_08410 antibody / N330_09809 antibody / N331_12425 antibody / N332_07371 antibody / N334_06317 antibody / N335_05489 antibody / PANDA_010362 antibody / PPP1R56 antibody / protein phosphatase 1 / regulatory subunit 56 antibody / TREES_T100008861 antibody / xCaspase-9 antibody / Y1Q_014900 antibody / Z169_14451 antibody
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Post-translational Modifications Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.; Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.
Tissue Specificity Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

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