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Anti-Caspase 9 antibody

[STJ96979] Download PDF Print Data Sheet

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Product name Anti-Caspase 9 antibody
Description Mouse Monoclonal to Caspase 9.
Host Mouse
Reactivity Chicken, Human, Mouse, Rat
Applications IP, WB
Immunogen Synthetic Peptide
Gene ID 842 (Human) /
Dilution range WB 1:1000-5000 / IP 1:200
Specificity The antibody detects endogenous Caspase 9 protein.
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clone ID Mar-20
Note For Research Use Only (RUO).
Protein Name Caspase-9 - CASP9 - MCH6 - ICE-LAP6 - APAF-3 - PPP1R56 - caspase 9
Clonality Monoclonal
Conjugation Unconjugated
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:P55211 Mouse UniPort/Swiss-Prot: Q8C3Q9 Rat UniProt/Swiss-Port: Q9JHK1 Human Entrez Gene: 842 Mouse Entrez Gene: 12371 Rat Entrez Gene: Rn.32199
Alternative Names CASP9 / caspase 9 / 25 kDa caspase-9 dominant negative protein antibody / A306_07035 antibody / Apaf3 antibody / APAF-3 antibody / apoptosis-related cysteine peptidase Casp9 antibody / apoptosis-related cysteine peptidase caspase 9 antibody / apoptotic protease activating factor 3 antibody / apoptotic protease-activating factor 3 antibody / apoptotic protease Mch-6 antibody / AS27_12949 antibody / CASP-9 antibody / casp9-A antibody / Casp-9-CTD antibody / Casp9_v1 antibody / caspase9 antibody / Caspase-9 antibody / caspase 9 / apoptosis-related cysteine peptidase antibody / caspase 9 / apoptosis-related cysteine protease antibody / caspase-9c antibody / caspase-9-carboxyl-terminal divergent antibody / caspase-9 dominant negative form antibody / caspase-9 isoform alpha preproprotein antibody / CB1_001086005 antibody / H920_17855 antibody / hypothetical protein antibody / iCasp9 antibody / Ice-Lap6 antibody / Ice-like apoptotic protease 6 antibody / M91_10958 antibody / M959_03272 antibody / mch6 antibody / MDA_GLEAN10024334 antibody / N300_01463 antibody / N302_12235 antibody / N303_02623 antibody / N305_00851 antibody / N306_07560 antibody / N307_01404 antibody / N308_14775 antibody / N310_04426 antibody / N311_02867 antibody / N312_05430 antibody / N320_07326 antibody / N325_04188 antibody / N326_05445 antibody / N327_06932 antibody / N328_02780 antibody / N329_08410 antibody / N330_09809 antibody / N331_12425 antibody / N332_07371 antibody / N334_06317 antibody / N335_05489 antibody / PANDA_010362 antibody / PPP1R56 antibody / protein phosphatase 1 / regulatory subunit 56 antibody / TREES_T100008861 antibody / xCaspase-9 antibody / Y1Q_014900 antibody / Z169_14451 antibody
Function Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP).; Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Post-translational Modifications Cleavages at Asp-315 by granzyme B and at Asp-330 by caspase-3 generate the two active subunits. Caspase-8 and -10 can also be involved in these processing events.; Phosphorylated at Thr-125 by MAPK1/ERK2. Phosphorylation at Thr-125 is sufficient to block caspase-9 processing and subsequent caspase-3 activation. Phosphorylation on Tyr-153 by ABL1/c-Abl; occurs in the response of cells to DNA damage.

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