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Anti-CD4 antibody

[STJ96972] Download PDF Print Data Sheet

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Product name Anti-CD4 antibody
Short Description Mouse Monoclonal to CD4.
Description CD4 is a protein encoded by the CD4 gene which is approximately 51,1 kDa. CD4 is localised to the cell membrane and endoplasmic reticulum. It is involved in the TGF-beta pathway, PEDF induced signalling and the T-cell receptor signalling pathway. It is a membrane glycoprotein of T-lymphocytes that interacts with major histocompatibility complex class II antigens and is also a receptor for the human immunodeficiency virus. It initiates or augments the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. CD4 is expressed in the blood, cells of the nervous system, liver, pancreas and spleen. STJ96972 was developed from clone 11A1 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This antibody detects endogenous CD4 proteins.
Applications IHC-p
Dilution range IHC 1:200
Specificity The antibody detects endogenous CD4 proteins.
Protein Name T-cell surface glycoprotein CD4 - CD4 - CD4 molecule
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 11A1
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 920 (Human) / 12504 (Mouse) / 24932 (Rat)
Gene Symbol CD4
Database Links Human UniProt/Swiss-Prot:P01730 Mouse UniPort/Swiss-Prot: P06332 Rat UniProt/Swiss-Port: P05540 Human Entrez Gene: 920 Mouse Entrez Gene: 12504 Rat Entrez Gene: Rn.10748
Alternative Names CD4 / CD4 molecule / CB1_000216001 antibody / CD4 4.3 protein antibody / CD4 antigen antibody / CD4 antigen (p55) antibody / CD4mut antibody / CD4 receptor antibody / cell surface glycoprotein CD4 antibody / D623_10009384 antibody / hypothetical protein antibody / I79_001406 antibody / L3T4 antibody / Ly-4 antibody / lymphocyte antigen CD4 antibody / M91_17644 antibody / M959_01769 antibody / MDA_GLEAN10016036 antibody / N300_14138 antibody / N302_08112 antibody / N331_09372 antibody / N332_05628 antibody / p55 antibody / PANDA_011253 antibody / precursor CD4 antibody / T-cell differentiation antigen L3T4 antibody / T-cell surface antigen T4 /Leu-3 antibody / T-cell surface glycoprotein CD4 antibody / T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4 /Leu-3) (T-cell differentiation antigen L3T4) antibody / TREES_T100008260 antibody / UY3_16427 antibody / W3 /25 antibody / W3 /25 antigen antibody / Z169_15824 antibody
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.; (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 .
Post-translational Modifications Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Localization Cell membrane Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

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