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Anti-CD4 antibody

[STJ96972] Download PDF Print Data Sheet

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Product name Anti-CD4 antibody
Description Mouse Monoclonal to CD4.
Host Mouse
Reactivity Human, Mouse, Rat
Applications IHC
Immunogen Synthetic Peptide
Gene ID 920 (Human) / 12504 (Mouse) / 24932 (Rat)
Dilution range IHC 1:200
Specificity The antibody detects endogenous CD4 proteins.
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clone ID 11A1
Note For Research Use Only (RUO).
Protein Name T-cell surface glycoprotein CD4 - CD4 - CD4 molecule
Clonality Monoclonal
Conjugation Unconjugated
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:P01730 Mouse UniPort/Swiss-Prot: P06332 Rat UniProt/Swiss-Port: P05540 Human Entrez Gene: 920 Mouse Entrez Gene: 12504 Rat Entrez Gene: Rn.10748
Alternative Names CD4 / CD4 molecule / CB1_000216001 antibody / CD4 4.3 protein antibody / CD4 antigen antibody / CD4 antigen (p55) antibody / CD4mut antibody / CD4 receptor antibody / cell surface glycoprotein CD4 antibody / D623_10009384 antibody / hypothetical protein antibody / I79_001406 antibody / L3T4 antibody / Ly-4 antibody / lymphocyte antigen CD4 antibody / M91_17644 antibody / M959_01769 antibody / MDA_GLEAN10016036 antibody / N300_14138 antibody / N302_08112 antibody / N331_09372 antibody / N332_05628 antibody / p55 antibody / PANDA_011253 antibody / precursor CD4 antibody / T-cell differentiation antigen L3T4 antibody / T-cell surface antigen T4 /Leu-3 antibody / T-cell surface glycoprotein CD4 antibody / T-cell surface glycoprotein CD4 precursor (T-cell surface antigen T4 /Leu-3) (T-cell differentiation antigen L3T4) antibody / TREES_T100008260 antibody / UY3_16427 antibody / W3 /25 antibody / W3 /25 antigen antibody / Z169_15824 antibody
Function Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.; (Microbial infection) Acts as a receptor for human immunodeficiency virus-1 . Down-regulated by HIV-1 Vpu . Acts as a receptor for Human Herpes virus 7/HHV-7 .
Post-translational Modifications Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
Cellular Localization Cell membrane Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.

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