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Anti-CHOP antibody

[STJ97774] Download PDF Print Data Sheet

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Product name Anti-CHOP antibody
Description Mouse Monoclonal to CHOP.
Host Mouse
Reactivity Human, Mouse, Rat
Applications IHC, WB
Immunogen synthetic peptide derived from CHOP
Gene ID 1649 (Human)
Dilution range WB 1:1000-2000 / IHC 1:100-200
Specificity CHOP Mouse Monoclonal Antibody (2B1) detects endogenous levels of DDIT3
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clone ID 2B1
Note For Research Use Only (RUO).
Protein Name DDIT3 - DDIT3 - CHOP10 - GADD153 - CHOP - DNA damage inducible transcript 3
Clonality Monoclonal
Conjugation Unconjugated
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:P35638 Mouse UniPort/Swiss-Prot: P35639 Rat UniProt/Swiss-Port: Q496Y7 Human Entrez Gene: 1649 Mouse Entrez Gene: 13198 Rat Entrez Gene: Rn.11183
Alternative Names DDIT3 / DNA damage inducible transcript 3 / Anapl_18134 antibody / AS27_01521 antibody / CB1_000607009 antibody / CCAAT /enhancer-binding protein homologous protein antibody / CCAAT /enhancer-binding protein-homologous protein antibody / C /EBP homologous protein antibody / C /EBP-homologous protein 10 antibody / C /EBP homoologous protein 10 antibody / C /EBP-like protein antibody / CEBPZ antibody / C /EBP zeta antibody / CHOP antibody / CHOP10 antibody / CHOP-10 antibody / DDIT-3 antibody / DNA damage-inducible transcript 3 antibody / DNA-damage inducible transcript 3 antibody / DNA-damage-inducible transcript 3 antibody / DNA damage-inducible transcript 3 protein antibody / DNA damage-inducible transcript 3 protein-like protein antibody / EGK_03839 antibody / gadd153 antibody / growth arrest and DNA damage-inducible antibody / growth arrest and DNA damage-inducible protein GADD153 antibody / growth arrest and DNA-damage-inducible protein GADD153 antibody / GW7_04685 antibody / H920_14021 antibody / MDA_GLEAN10006654 antibody / N300_09522 antibody / N301_00809 antibody / N335_09969 antibody / PAL_GLEAN10004864 antibody / PANDA_004123 antibody / transcription factor GADD153 antibody / TREES_T100018363 antibody / UY3_00745 antibody / Xchop antibody / Y1Q_008040 antibody / Y956_02569 antibody
Function Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2 and MYOD1, ATF4-dependent transcriptional activation of asparagine synthetase (ASNS), CEBPA-dependent transcriptional activation of hepcidin (HAMP) and CEBPB-mediated expression of peroxisome proliferator-activated receptor gamma (PPARG). Inhibits the canonical Wnt signaling pathway by binding to TCF7L2/TCF4, impairing its DNA-binding properties and repressing its transcriptional activity. Plays a regulatory role in the inflammatory response through the induction of caspase-11 (CASP4/CASP11) which induces the activation of caspase-1 (CASP1) and both these caspases increase the activation of pro-IL1B to mature IL1B which is involved in the inflammatory response.
Sequence and Domain Family The N-terminal region is necessary for its proteasomal degradation, transcriptional activity and interaction with EP300/P300.
Post-translational Modifications Ubiquitinated, leading to its degradation by the proteasome. ; Phosphorylation at serine residues by MAPK14 enhances its transcriptional activation activity while phosphorylation at serine residues by CK2 inhibits its transcriptional activation activity.
Cellular Localization Cytoplasm. Nucleus. Note=Present in the cytoplasm under non-stressed conditions and ER stress leads to its nuclear accumulation.

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