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Anti-Cleaved-Caspase-1 (D210) antibody

[STJ90001] Download PDF Print Data Sheet

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Product name Anti-Cleaved-Caspase-1 (D210) antibody
Short Description Rabbit Polyclonal to Cleaved-Caspase-1 (D210).
Description Caspase-1 is a protein encoded by the CASP1 gene which is approximately 45,1 kDa. Caspase-1 is localised to the cytoplasm. It is involved in amyotrophic lateral sclerosis, toll-like receptor signalling pathways, p53 signalling and the TNFR1 pathway. This protein falls under the the cysteine-aspartic acid protease family. upon activation It plays a central role in the execution-phase of cell apoptosis. These enzymes can be divided into initiators and effectors. The initiator isoforms are activated by, and interact with, upstream adaptor molecules. Caspase-1 is expressed mainly in the spleen and lung. Mutations in the CASP1 gene may result in shigellosis and cowpox. STJ90001 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of fragment activated Caspase-1 protein resulting from cleavage adjacent to D210.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:10000 /
Specificity Cleaved-Caspase-1 (D210) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.
Protein Name Caspase-1 - CASP1 - ICE - IL1BC - caspase 1
Immunogen Synthesized peptide derived from human Caspase-1
Immunogen Region 130-210 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 834 (Human) /
Gene Symbol CASP1
Molecular Weight 25/45 kDa
Database Links Human UniProt/Swiss-Prot:P29466 Mouse UniPort/Swiss-Prot: P29452 Rat UniProt/Swiss-Port: Q91W32 Human Entrez Gene: 834 Mouse Entrez Gene: 12362 Rat Entrez Gene: Rn.37508
Alternative Names CASP1 / caspase 1 / aspartate-specific cysteinyl-1 antibody / CASP-1 antibody / casp1a antibody / CASP1 nirs variant 1 antibody / CASP4 antibody / caspase-1 antibody / Caspase-13 antibody / caspase 1 / apoptosis-related cysteine peptidase antibody / caspase 1 / apoptosis-related cysteine peptidase (interleukin 1 / beta / convertase) antibody / caspase 1 / apoptosis-related cysteine protease (interleukin 1 / beta / convertase) antibody / caspase-1 /caspase-4 hybrid antibody / caspase-1 isoform alpha antibody / caspase 4 / apoptosis-related cysteine peptidase antibody / GW7_16661 antibody / Ice antibody / IL1BC antibody / IL-1BC antibody / IL1B-convertase antibody / IL-1B converting enzyme antibody / IL-1 beta-converting enzyme antibody / interleukin 1-B converting enzyme antibody / interleukin 1 / beta / convertase antibody / interleukin-1 beta convertase antibody / interleukin 1 beta-converting enzyme antibody / interleukin-1 beta converting enzyme antibody / interleukin-1 beta-converting enzyme antibody / interleukin-1beta-converting enzyme antibody / Interleukin 1beta converting enzyme antibody / M91_05575 antibody / P45 antibody / xice antibody
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive .
Post-translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cellular Localization Cytoplasm.
Tissue Specificity Expressed in larger amounts in spleen and lung. Detected in liver, heart, small intestine, colon, thymus, prostate, skeletal muscle, peripheral blood leukocytes, kidney and testis. No expression in the brain.

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