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Anti-Cleaved-Caspase-1 (D210) antibody

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Product name Anti-Cleaved-Caspase-1 (D210) antibody
Description Rabbit Polyclonal to Cleaved-Caspase-1 (D210).
Host Rabbit
Reactivity Human
Applications ELISA, IHC, WB
Immunogen Synthesized peptide derived from human Caspase-1
Gene ID 834 (Human) /
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:10000 /
Specificity Cleaved-Caspase-1 (D210) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-1 protein resulting from cleavage adjacent to D210.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note For Research Use Only (RUO).
Protein Name Caspase-1 - CASP1 - ICE - IL1BC - caspase 1
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:P29466 Mouse UniPort/Swiss-Prot: P29452 Rat UniProt/Swiss-Port: Q91W32 Human Entrez Gene: 834 Mouse Entrez Gene: 12362 Rat Entrez Gene: Rn.37508
Alternative Names CASP1 / caspase 1 / aspartate-specific cysteinyl-1 antibody / CASP-1 antibody / casp1a antibody / CASP1 nirs variant 1 antibody / CASP4 antibody / caspase-1 antibody / Caspase-13 antibody / caspase 1 / apoptosis-related cysteine peptidase antibody / caspase 1 / apoptosis-related cysteine peptidase (interleukin 1 / beta / convertase) antibody / caspase 1 / apoptosis-related cysteine protease (interleukin 1 / beta / convertase) antibody / caspase-1 /caspase-4 hybrid antibody / caspase-1 isoform alpha antibody / caspase 4 / apoptosis-related cysteine peptidase antibody / GW7_16661 antibody / Ice antibody / IL1BC antibody / IL-1BC antibody / IL1B-convertase antibody / IL-1B converting enzyme antibody / IL-1 beta-converting enzyme antibody / interleukin 1-B converting enzyme antibody / interleukin 1 / beta / convertase antibody / interleukin-1 beta convertase antibody / interleukin 1 beta-converting enzyme antibody / interleukin-1 beta converting enzyme antibody / interleukin-1 beta-converting enzyme antibody / interleukin-1beta-converting enzyme antibody / Interleukin 1beta converting enzyme antibody / M91_05575 antibody / P45 antibody / xice antibody
Function Thiol protease that cleaves IL-1 beta between an Asp and an Ala, releasing the mature cytokine which is involved in a variety of inflammatory processes. Important for defense against pathogens. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Can also promote apoptosis. Upon inflammasome activation, during DNA virus infection but not RNA virus challenge, controls antiviral immunity through the cleavage of MB21D1/cGAS, rendering it inactive .
Post-translational Modifications The two subunits are derived from the precursor sequence by an autocatalytic mechanism.
Cellular Localization Cytoplasm.

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