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Anti-Cleaved-Caspase-3 p17 (D175) antibody

[STJ90005] Download PDF Print Data Sheet
Western blot (WB) analysis of Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody.

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Product name Anti-Cleaved-Caspase-3 p17 (D175) antibody
Description Rabbit Polyclonal to Cleaved-Caspase-3 p17 (D175).
Host Rabbit
Reactivity Human, Mouse, Rat
Applications ELISA, IHC, WB
Immunogen Synthesized peptide derived from human Caspase-3 p17
Gene ID 836 (Human) / 12367 (Mouse) / 25402 (Rat)
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:20000 /
Specificity Cleaved-Caspase-3 p17 (D175) Polyclonal Antibody detects endogenous levels of fragment of activated Caspase-3 p17 protein resulting from cleavage adjacent to D175.
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Note For Research Use Only (RUO).
Protein Name Caspase-3 - CASP3 - CPP32 - CPP32B - Yama - apopain - caspase 3
Clonality Polyclonal
Conjugation Unconjugated
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:P42574 Mouse UniPort/Swiss-Prot: P70677 Rat UniProt/Swiss-Port: P55213 Human Entrez Gene: 836 Mouse Entrez Gene: 12367 Rat Entrez Gene: Rn.10562
Alternative Names CASP3 / caspase 3 / AC-3 antibody / Apopain antibody / CASP-3 antibody / casp3 protein antibody / Caspase-3 antibody / caspase 3A antibody / caspase 3 / apoptosis-related cysteine peptidase antibody / caspase 3 / apoptosis related cysteine protease antibody / caspase 3 / apoptosis-related cysteine protease antibody / Caspase 3 apoptosis related cysteine protease (ICE-like cysteine protease) antibody / Caspase 3 / apoptosis related cysteine protease (ICE-like cysteine protease) antibody / caspase 3-like antibody / Caspase-3-like protein antibody / caspase-3-like protein 1 antibody / caspase-3 preproprotein antibody / CB1_000998003 antibody / CC3 antibody / cpp32 antibody / CPP-32 antibody / CPP32B antibody / CPP32beta antibody / Cysteine protease CPP32 antibody / GW7_02720 antibody / H920_14272 antibody / hypothetical protein antibody / IRP antibody / Lice antibody / MDA_GLEAN10021003 antibody / mldy antibody / PAL_GLEAN10021656 antibody / PANDA_001909 antibody / PARP cleavage protease antibody / procaspase3 antibody / Protein Yama antibody / SCA-1 antibody / SREBP cleavage activity 1 antibody / UY3_01982 antibody / xCPP32 antibody / Y1Q_030565 antibody / Yama antibody / yama protein antibody
Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Post-translational Modifications Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.; S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
Cellular Localization Cytoplasm.

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