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Anti-COL3A1 antibody

[STJ92388] Download PDF Print Data Sheet
Anti-COL3A1 antibody

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Product name Anti-COL3A1 antibody
Short Description Rabbit Polyclonal to COL3A1.
Description COL3A1 is a protein encoded by the COL3A1 gene which is approximately 138,5 kDa. COL3A1 is secreted into the extracellular space and matrix. It is involved in collagen chain trimerization, integrin pathway, ERK signalling, phospholipase-C pathway and binding and uptake of ligands by scavenger receptors. It is involved in regulation of cortical development and is a major ligand of ADGRG1 in the developing brain. COL3A1 is expressed in skin, pancreas, bone, liver and lung. Mutations in the COL3A1 gene result in Ehlers-Danlos syndrome and thoracic aortic aneurysms. STJ92388 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of COL3A1 protein.
Applications IHC-p, ELISA, ICC, IF
Dilution range IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:10000 /
Specificity COL3A1 Polyclonal Antibody detects endogenous levels of COL3A1 protein.
Protein Name Collagen alpha-1(III) chain - COL3A1 - EDS4A - collagen type III alpha 1 chain
Immunogen Synthesized peptide derived from human COL3A1
Immunogen Region 50-130 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1281 (Human) / 12825 (Mouse) / 84032 (Rat)
Gene Symbol COL3A1
Molecular Weight 95 kDa
Database Links Human UniProt/Swiss-Prot:P02461 Mouse UniPort/Swiss-Prot: P08121 Rat UniProt/Swiss-Port: P13941 Human Entrez Gene: 1281 Mouse Entrez Gene: 12825 Rat Entrez Gene: Rn.3247
Alternative Names COL3A1 / collagen type III alpha 1 / A306_13699 antibody / alpha1 (III) collagen antibody / alpha 1 type III collagen antibody / alpha-1 type III collagen antibody / AS27_08750 antibody / AS28_05033 antibody / CB1_001183009 antibody / Col3a-1 antibody / collagen antibody / Collagen alpha-1(II) chain antibody / collagen alpha-1(III) chain antibody / collagen alpha-1(III) chain-like antibody / collagen alpha-1(III) chain preproprotein antibody / collagen alpha 1 type III antibody / collagen / fetal antibody / collagen type III antibody / collagen / type III / alpha 1 antibody / collagen / type III / alpha 1 chain / fibril forming antibody / collagen / type III / alpha 1 (Ehlers-Danlos syndrome type IV / autosomal dominant) antibody / D623_10008782 antibody / EDS4A antibody / Ehlers-Danlos syndrome type IV / autosomal dominant antibody / H920_10639 antibody / hypothetical protein antibody / I79_024950 antibody / M959_07763 antibody / MDA_GLEAN10023626 antibody / N300_13536 antibody / N301_02386 antibody / N306_03184 antibody / N307_05624 antibody / N308_05317 antibody / N309_09026 antibody / N311_03018 antibody / N312_03096 antibody / N321_04490 antibody / N326_02911 antibody / N327_10663 antibody / N329_12206 antibody / N330_02653 antibody / N331_02456 antibody / N332_00931 antibody / N333_09113 antibody / N334_05261 antibody / N336_05755 antibody / PANDA_007210 antibody / pro-alpha-1 type 3 collagen antibody / pro alpha 1 type III collagen antibody / procollagen alpha-1 type III antibody / procollagen / type III / alpha 1 antibody / Tsk2 antibody / Tsk-2 antibody / type III collagen antibody / UY3_16679 antibody / Y1Q_001429 antibody / Y956_03992 antibody / Z169_07091 antibody
Function Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Post-translational Modifications Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. ; O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Cellular Localization Secreted, extracellular space, extracellular matrix
Sequence and Domain Family The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.

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