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Anti-Collagen III antibody

[STJ97025] Download PDF Print Data Sheet

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Product name Anti-Collagen III antibody
Description Mouse Monoclonal to Collagen III.
Host Mouse
Reactivity Human, Mouse, Rat
Applications WB
Immunogen Synthetic Peptide
Gene ID 1281 (Human) / 12825 (Mouse) / 84032 (Rat)
Dilution range WB 1:1000
Specificity The antibody detects endogenous Collagen III protein.
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clone ID Q76
Note For Research Use Only (RUO).
Protein Name Collagen alpha-1(III) chain - COL3A1 - EDS4A - collagen type III alpha 1 chain
Clonality Monoclonal
Conjugation Unconjugated
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:P02461 Mouse UniPort/Swiss-Prot: P08121 Rat UniProt/Swiss-Port: P13941 Human Entrez Gene: 1281 Mouse Entrez Gene: 12825 Rat Entrez Gene: Rn.3247
Alternative Names COL3A1 / collagen type III alpha 1 / A306_13699 antibody / alpha1 (III) collagen antibody / alpha 1 type III collagen antibody / alpha-1 type III collagen antibody / AS27_08750 antibody / AS28_05033 antibody / CB1_001183009 antibody / Col3a-1 antibody / collagen antibody / Collagen alpha-1(II) chain antibody / collagen alpha-1(III) chain antibody / collagen alpha-1(III) chain-like antibody / collagen alpha-1(III) chain preproprotein antibody / collagen alpha 1 type III antibody / collagen / fetal antibody / collagen type III antibody / collagen / type III / alpha 1 antibody / collagen / type III / alpha 1 chain / fibril forming antibody / collagen / type III / alpha 1 (Ehlers-Danlos syndrome type IV / autosomal dominant) antibody / D623_10008782 antibody / EDS4A antibody / Ehlers-Danlos syndrome type IV / autosomal dominant antibody / H920_10639 antibody / hypothetical protein antibody / I79_024950 antibody / M959_07763 antibody / MDA_GLEAN10023626 antibody / N300_13536 antibody / N301_02386 antibody / N306_03184 antibody / N307_05624 antibody / N308_05317 antibody / N309_09026 antibody / N311_03018 antibody / N312_03096 antibody / N321_04490 antibody / N326_02911 antibody / N327_10663 antibody / N329_12206 antibody / N330_02653 antibody / N331_02456 antibody / N332_00931 antibody / N333_09113 antibody / N334_05261 antibody / N336_05755 antibody / PANDA_007210 antibody / pro-alpha-1 type 3 collagen antibody / pro alpha 1 type III collagen antibody / procollagen alpha-1 type III antibody / procollagen / type III / alpha 1 antibody / Tsk2 antibody / Tsk-2 antibody / type III collagen antibody / UY3_16679 antibody / Y1Q_001429 antibody / Y956_03992 antibody / Z169_07091 antibody
Function Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Sequence and Domain Family The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Post-translational Modifications Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. ; O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Cellular Localization Secreted, extracellular space, extracellular matrix


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