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Anti-Collagen III antibody

[STJ97025] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Collagen III antibody
Short Description Mouse Monoclonal to Collagen III.
Description Collagen III is a protein encoded by the COL3A1 gene which is approximately 138,5 kDa. Collagen III is secreted into the extracellular matrix. It is involved in collagen chain trimerization, the integrin pathway, ERK signalling and the phospholipase-C pathway. It occurs in most soft connective tissues along with type I collagen. It is involved in regulation of cortical development and is the major ligand of ADGRG1 in the developing brain, binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13. Collagen III is expressed in the skin, pancreas, bone, liver and lung. Mutations in the COL3A1 gene may result in Ehlers-Danlos syndrome. STJ97025 was developed from clone Q76 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous Collagen III protein.
Applications WB
Dilution range WB 1:1000
Specificity The antibody detects endogenous Collagen III protein.
Protein Name Collagen alpha-1
III chain
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID Q76
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1281
Gene Symbol COL3A1
Database Links HGNC:2201
OMIM:120180
Alternative Names COL3A1 antibody
Collagen alpha-1 antibody
III chain antibody
Function Collagen type III occurs in most soft connective tissues along with type I collagen. Involved in regulation of cortical development. Is the major ligand of ADGRG1 in the developing brain and binding to ADGRG1 inhibits neuronal migration and activates the RhoA pathway by coupling ADGRG1 to GNA13 and possibly GNA12.
Post-translational Modifications Proline residues at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains. ; O-linked glycan consists of a Glc-Gal disaccharide bound to the oxygen atom of a post-translationally added hydroxyl group.
Cellular Localization Secreted, extracellular space, extracellular matrix
Sequence and Domain Family The C-terminal propeptide, also known as COLFI domain, have crucial roles in tissue growth and repair by controlling both the intracellular assembly of procollagen molecules and the extracellular assembly of collagen fibrils. It binds a calcium ion which is essential for its function.
Swiss-Prot Key P02461_HUMAN
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1
I am interested in this antibody in 0.3mg size, 1mg/mL. Would it be possible to change the storage buffer to PBS and not include sodium azide?
Question by: Guest on 11 Apr 2018 13:40:00
-3
Hello, thank you for your query. If you would like to place a custom order, the product should be at least 1 mg. There will be no additional cost for changing the storage buffer. Please contact us at info@stjohnslabs.com for further information.
Answer by: Customer Support on 11 Apr 2018 13:43:00

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