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Anti-Connexin 43 antibody

[STJ92411] Download PDF Print Data Sheet

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Product name Anti-Connexin 43 antibody
Short Description Rabbit Polyclonal to Connexin 43.
Description Connexin 43 is a protein encoded by the GJA1 gene which is approximately 43 kDa. Connexin 43 is localised to the cell membrane and endoplasmic reticulum. It is involved in gap junction trafficking and transport of connexins along the secretory pathway. It is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. In the heart these gap junctions are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. Connexin 43 is expressed in the heart and foetal cochlea. Mutations in the GJA1 gene may result in Oculodentodigital dysplasia. STJ92411 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Connexin 43 protein.
Applications IHC-p, ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:10000 /
Specificity Connexin 43 Polyclonal Antibody detects endogenous levels of Connexin 43 protein.
Protein Name Gap junction alpha-1 protein - GJA1 - CX43 - ODD - ODOD - SDTY3 - ODDD - GJAL - gap junction protein alpha 1
Immunogen Synthesized peptide derived from human Connexin 43
Immunogen Region 310-390 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 2697 (Human) / 14609 (Mouse) / 24392 (Rat)
Gene Symbol GJA1
Molecular Weight 43 kDa
Database Links Human UniProt/Swiss-Prot:P17302 Mouse UniPort/Swiss-Prot: P23242 Rat UniProt/Swiss-Port: P08050 Human Entrez Gene: 2697 Mouse Entrez Gene: 14609 Rat Entrez Gene: Rn.10346
Alternative Names GJA1 / gap junction protein alpha 1 / alpha 1 connexin antibody / alpha 1 gap junction protein antibody / Anapl_08679 antibody / AS27_05534 antibody / AS28_11841 antibody / AVSD3 antibody / CB1_001251004 antibody / CMDR antibody / Cnx43 antibody / connexin43 antibody / connexin 43 antibody / connexin-43 antibody / connexin 47 antibody / CX43 antibody / Cx43alpha1 antibody / D623_10035611 antibody / dfnb38 antibody / EGK_15392 antibody / EH28_01091 antibody / EKVP antibody / gap junction 43 kDa heart protein antibody / Gap junction alpha-1 protein antibody / gap junction membrane channel protein alpha 1 antibody / gap junction protein antibody / gap junction protein / alpha 1 antibody / gap junction protein / alpha 1 / 43kDa antibody / gap junction protein / alpha 1 / 43kDa (connexin 43) antibody / gap junction protein / alpha 1 / 43 kD (connexin 43) antibody / gap junction protein connexin 43 antibody / Gja-1 antibody / gja1-A antibody / gjal antibody / GW7_15987 antibody / HLHS1 antibody / HSS antibody / M91_18979 antibody / M959_14711 antibody / N300_09577 antibody / N301_05530 antibody / N302_02818 antibody / N305_09280 antibody / N306_14862 antibody / N307_07974 antibody / N308_03124 antibody / N309_03765 antibody / N312_02220 antibody / N320_02821 antibody / N321_02191 antibody / N322_00588 antibody / N324_11803 antibody / N325_05039 antibody / N327_12583 antibody / N328_04039 antibody / N329_12930 antibody / N330_07279 antibody / N331_11682 antibody / N332_02228 antibody / N333_03010 antibody / N334_03913 antibody / N335_00607 antibody / N336_11621 antibody / N339_08715 antibody / N340_03196 antibody / N341_01954 antibody / Npm1 antibody / ODDD antibody / PAL_GLEAN10018663 antibody / PANDA_011866 antibody / PPKCA antibody / TREES_T100012753 antibody / UY3_16484 antibody / vascular smooth muscle connexin-43 antibody / Y1Q_019970 antibody / Y956_00406 antibody / Z169_03552 antibody
Function Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. May play a critical role in the physiology of hearing by participating in the recycling of potassium to the cochlear endolymph. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract (By similarity). May play a role in cell growth inhibition through the regulation of NOV expression and localization. Plays an essential role in gap junction communication in the ventricles (By similarity).
Post-translational Modifications Phosphorylated at Ser-368 by PRKCG; phosphorylation induces disassembly of gap junction plaques and inhibition of gap junction activity (By similarity). Phosphorylation at Ser-325, Ser-328 and Ser-330 by CK1 modulates gap junction assembly. Phosphorylation at Ser-368 by PRKCD triggers its internalization into small vesicles leading to proteasome-mediated degradation (By similarity). ; Sumoylated with SUMO1, SUMO2 and SUMO3, which may regulate the level of functional Cx43 gap junctions at the plasma membrane. May be desumoylated by SENP1 or SENP2. ; S-nitrosylation at Cys-271 is enriched at the muscle endothelial gap junction in arteries, it augments channel permeability and may regulate of smooth muscle cell to endothelial cell communication.
Cellular Localization Cell membrane Cell junction, gap junction Endoplasmic reticulum Note=Localizes at the intercalated disk (ICD) in cardiomyocytes and the proper localization at ICD is dependent on TMEM65.
Tissue Specificity Expressed in the heart and fetal cochlea.


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