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Anti-Cyclin B1 antibody

[STJ92534] Download PDF Print Data Sheet

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Product name Anti-Cyclin B1 antibody
Short Description Rabbit Polyclonal to Cyclin B1.
Description Cyclin B1 is a protein encoded by the CCNB1 gene which is approximately 48,3 kDa. Cyclin B1 is localised to the cytoplasm and nucleus. It is involved in CDK-mediated phosphorylation and removal of Cdc6, regulation of PLK1 activity at G2/M transition and DNA damage response. This protein falls under the highly conserved cyclin family. It is a regulatory protein involved in mitosis. It forms a complex with p34(cdc2) to form the maturation-promoting factor. Cyclin B1 is expressed in the nervous system, skin, intestine, liver and lung. Mutations in the CCNB1 gene may result in thyroid lymphoma and cervical cancer. STJ92534 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Cyclin B1 protein.
Applications IHC-p, ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:20000 /
Specificity Cyclin B1 Polyclonal Antibody detects endogenous levels of Cyclin B1 protein.
Protein Name G2/mitotic-specific cyclin-B1 - CCNB1 - CCNB - cyclin B1
Immunogen Synthesized peptide derived from human Cyclin B1 around the non-phosphorylation site of S126.
Immunogen Region 60-140 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 891 (Human) / 268697 (Mouse) / 25203 (Rat)
Gene Symbol CCNB1
Molecular Weight 60 kDa
Database Links Human UniProt/Swiss-Prot:P14635 Mouse UniPort/Swiss-Prot: P24860 Rat UniProt/Swiss-Port: P30277 Human Entrez Gene: 891 Mouse Entrez Gene: 268697 Rat Entrez Gene: Rn.9232
Alternative Names CCNB1 / cyclin B1 / AS27_15469 antibody / AS28_06256 antibody / CB1_000781005 antibody / CCNB antibody / Ccnb1-rs1 antibody / Ccnb1-rs13 antibody / cycb antibody / cycb1 antibody / Cycb1-rs1 antibody / Cycb-4 antibody / Cycb-5 antibody / cyclinB antibody / cyclin B antibody / cyclin B1 / related sequence 1 antibody / cyclin B1 / related sequence 13 antibody / cyclin B4 antibody / EGK_16552 antibody / etID61116.5 antibody / G2 /mitotic-specific cyclin B1 antibody / G2 /mitotic-specific cyclin-B1 antibody / g2 /mitotic-specific cyclin-B1-like protein antibody / GW7_03529 antibody / hypothetical protein antibody / I79_013589 antibody / M91_09437 antibody / M959_08789 antibody / N301_04089 antibody / N306_11177 antibody / N309_09220 antibody / N312_09798 antibody / N320_10114 antibody / N321_09928 antibody / N322_08992 antibody / N327_00266 antibody / N328_00237 antibody / N334_11683 antibody / N335_14437 antibody / N336_00235 antibody / PANDA_003963 antibody / TREES_T100016553 antibody / UY3_06301 antibody / Y1Q_010726 antibody / Y956_11456 antibody
Function Essential for the control of the cell cycle at the G2/M (mitosis) transition.
Post-translational Modifications Ubiquitinated by the SCF(NIPA) complex during interphase, leading to its destruction. Not ubiquitinated during G2/M phases. ; Phosphorylated by PLK1 at Ser-133 on centrosomes during prophase: phosphorylation by PLK1 does not cause nuclear import. Phosphorylation at Ser-147 was also reported to be mediated by PLK1 but Ser-133 seems to be the primary phosphorylation site.
Cellular Localization Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.

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