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Anti-DCAMKL2 antibody

[STJ92663] Download PDF Print Data Sheet

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Product name Anti-DCAMKL2 antibody
Short Description Rabbit Polyclonal to DCAMKL2.
Description DCAMKL2 is a protein encoded by the DCLK2 gene which is approximately 83,6 kDa. DCAMKL2 is localised to the cytoplasm and is involved in transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. This protein falls under the protein kinase superfamily and the doublecortin family. It contains two N-terminal doublecortin domains, which bind microtubules and regulate microtubule polymerization. It also contains a C-terminal serine/threonine protein kinase domain, which shows substantial homology to Ca2+/calmodulin-dependent protein kinase. DCAMKL2 is expressed in the brain, heart and eye. The absence of this protein results in a severe epileptic phenotype and lethality. STJ92663 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of DCAMKL2 protein.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IF 1:200-1:1000 / ELISA 1:10000 /
Specificity DCAMKL2 Polyclonal Antibody detects endogenous levels of DCAMKL2 protein.
Protein Name Serine/threonine-protein kinase DCLK2 - DCLK2 - MGC45428 - DCDC3 - DCDC3B - DCK2 - DCAMKL2 - doublecortin like kinase 2
Immunogen Synthesized peptide derived from human DCAMKL2
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 166614 (Human) / 70762 (Mouse) /
Gene Symbol DCLK2
Molecular Weight 83 kDa
Database Links Human UniProt/Swiss-Prot:Q8N568 Mouse UniPort/Swiss-Prot: Q6PGN3 Rat UniProt/Swiss-Port: Q5MPA9 Human Entrez Gene: 166614 Mouse Entrez Gene: 70762 Rat Entrez Gene: Rn.23327
Alternative Names DCLK2 / doublecortin like kinase 2 / A306_08261 antibody / AS27_05746 antibody / AS28_03159 antibody / caMK-like CREB regulatory kinase 2 antibody / CL2 antibody / CLICK2 antibody / CLICK-II antibody / CLIK2 antibody / Dcamkl2 antibody / DCDC3 antibody / DCDC3B antibody / Dck2 antibody / doublecortin and CaM kinase-like 1 antibody / doublecortin and CaM kinase-like 2 antibody / doublecortin domain-containing protein 3B antibody / doublecortin kinase 2 antibody / doublecortin-like and CAM kinase-like 2 antibody / doublecortin-like kinase 2 antibody / H920_08937 antibody / hypothetical protein antibody / M91_10215 antibody / M959_05152 antibody / MDA_GLEAN10020491 antibody / N300_03068 antibody / N301_03941 antibody / N302_06082 antibody / N303_14312 antibody / N305_05254 antibody / N306_02034 antibody / N308_06517 antibody / N309_15604 antibody / N311_12595 antibody / N312_04294 antibody / N321_13461 antibody / N322_06564 antibody / N324_07600 antibody / N326_12272 antibody / N328_09171 antibody / N329_12109 antibody / N331_01151 antibody / N332_04969 antibody / N333_01043 antibody / N334_11319 antibody / N335_03924 antibody / N336_01405 antibody / N340_12353 antibody / PAL_GLEAN10016605 antibody / PANDA_020009 antibody / RGD1308384 antibody / Serine /threonine-protein kinase DCLK2 antibody / TREES_T100005715 antibody / UY3_03120 antibody / Y1Q_007206 antibody / Y956_01825 antibody / Z169_05734 antibody
Function Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm (By similarity).
Post-translational Modifications Autophosphorylated.
Cellular Localization Cytoplasm, cytoskeleton. Note=Colocalizes with microtubules.
Tissue Specificity Expressed in the brain, heart and eyes.
Sequence and Domain Family The doublecortin domains are involved in the colocalization with microtubules.


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