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Anti-EEA1 antibody

[STJ96393] Download PDF Print Data Sheet

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Product name Anti-EEA1 antibody
Short Description Rabbit Polyclonal to EEA1.
Description EEA1 is a protein encoded by the EEA1 gene which is approximately 162,5 kDa. EEA1 is localised to the cytoplasm and is involved in the innate immune system, activated TLR4 signalling and sorting endosome formation in CF. It binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking. EEA1 is expressed in the liver, eye, heart, pancreas and adrenal gland. Mutations in the EEA1 gene may result in Bartonellosis and Cutaneous Lupus Erythematosus. STJ96393 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of EEA1 protein.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000 / ELISA 1:20000 /
Specificity EEA1 Polyclonal Antibody detects endogenous levels of EEA1 protein.
Protein Name Early endosome antigen 1 - EEA1 - ZFYVE2 - early endosome antigen 1
Immunogen Synthesized peptide derived from human EEA1.
Immunogen Region N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8411 (Human) / 216238 (Mouse) /
Gene Symbol EEA1
Molecular Weight 162 kDa
Database Links Human UniProt/Swiss-Prot:Q15075 Mouse UniPort/Swiss-Prot: Q8BL66 Human Entrez Gene: 8411 Mouse Entrez Gene: 216238 Rat Entrez Gene: Rn.23513
Alternative Names EEA1 / early endosome antigen 1 / A306_06786 antibody / AS27_11603 antibody / AS28_05603 antibody / CB1_000508001 antibody / D623_10028741 antibody / early endosome antigen 1 / 162kD antibody / Early endosome antigen 1-like protein antibody / early endosome-associated protein antibody / endosome-associated protein p162 antibody / H920_07464 antibody / I79_018911 antibody / MDA_GLEAN10011247 antibody / MST105 antibody / MSTP105 antibody / N300_14814 antibody / N301_14729 antibody / N303_06977 antibody / N305_07679 antibody / N306_04217 antibody / N308_05463 antibody / N309_06722 antibody / N310_08024 antibody / N312_01054 antibody / N320_03178 antibody / N321_04338 antibody / N324_12656 antibody / N325_01885 antibody / N326_01815 antibody / N327_04926 antibody / N328_00080 antibody / N332_06035 antibody / N333_13129 antibody / N334_04398 antibody / N335_14412 antibody / N339_05325 antibody / N341_03147 antibody / PAL_GLEAN10022465 antibody / TREES_T100009236 antibody / UY3_17581 antibody / Y1Q_017655 antibody / Y956_04042 antibody / Z169_09290 antibody / zfyve2 antibody / zinc finger FYVE domain-containing protein 2 antibody
Function Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate and participates in endosomal trafficking.
Cellular Localization Cytoplasm. Early endosome membrane; Peripheral membrane protein.
Sequence and Domain Family The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions.

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