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Anti-Egr-2 antibody

[STJ92863] Download PDF Print Data Sheet

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Product name Anti-Egr-2 antibody
Short Description Rabbit Polyclonal to Egr-2.
Description Egr-2 is a protein encoded by the EGR2 gene which is approximately 50,3 kDa. Egr-2 is localised to the nucleus and is involved in toll-like receptor signalling pathway, HTLV-I infection, viral carcinogenesis and developmental biology. It is a sequence-specific DNA-binding transcription factor, it binds to two specific DNA sites located in the promoter region of HOXA4. It is also an E3 SUMO-protein ligase, helping SUMO1 conjugate to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. Egr-2 is expressed in the cells of the nervous system. Mutations in the EGR2 gene may result in congenital hypomyelinatingand Charcot-Marie-tooth disease. STJ92863 was purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. This antibody binds to endogenous Egr-2.
Applications IHC-p, ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:20000 /
Specificity Egr-2 Polyclonal Antibody detects endogenous levels of Egr-2 protein.
Protein Name Early growth response protein 2 - EGR1 - TIS8 - G0S30 - NGFI-A - KROX-24 - ZIF-268 - AT225 - ZNF225 - early growth response 1
Immunogen Synthesized peptide derived from human Egr-2
Immunogen Region 340-420 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 1958/1959 (Human) / 13653/13654 (Mouse) / 24330/114090 (Rat)
Gene Symbol EGR1
Molecular Weight 50 kDa
Database Links Human UniProt/Swiss-Prot:P18146 Human Entrez Gene: 1958
Alternative Names EGR1 / early growth response 1 / Anapl_07333 antibody / AS27_12135 antibody / AS28_00672 antibody / at225 antibody / CB1_000475030 antibody / early growth response protein 1 antibody / Early growth response protein 1-B antibody / egr antibody / EGR-1 antibody / EH28_16230 antibody / etID309970.14 antibody / ETR103 antibody / G0S30 antibody / GW7_10089 antibody / H920_19243 antibody / hypothetical protein antibody / Krox-1 antibody / krox24 antibody / Krox-24 antibody / Krox-24 nuclear protein antibody / M959_11586 antibody / MDA_GLEAN10012472 antibody / N300_10982 antibody / N302_05414 antibody / N303_10875 antibody / N305_06788 antibody / N307_00714 antibody / N308_09169 antibody / N309_05222 antibody / N311_05680 antibody / N312_05942 antibody / N324_04236 antibody / N331_09560 antibody / N333_03429 antibody / N334_09687 antibody / N336_10702 antibody / N341_11001 antibody / nerve growth factor-induced protein A antibody / Ngf1 antibody / NGF1-A antibody / Ngfi antibody / ngfi-a antibody / NGFIA antibody / PAL_GLEAN10016817 antibody / PANDA_011792 antibody / TIS8 antibody / transcription factor ETR103 antibody / transcription factor Zif268 antibody / TREES_T100011343 antibody / UY3_11906 antibody / Xegr-1 antibody / Y1Q_007543 antibody / Y956_02330 antibody / Z169_06195 antibody / Zenk antibody / Zfp-6 antibody / zif-268 antibody / Zif268 antibody / zinc finger protein 225 antibody / zinc finger protein Krox-24 antibody / zinc finger protein ZENK antibody / zinc-finger transcriptional protein antibody / ZNF225 antibody
Function Transcriptional regulator . Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes (By similarity). Binds double-stranded target DNA, irrespective of the cytosine methylation status . Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Activates expression of p53/TP53 and TGFB1, and thereby helps prevent tumor formation. Required for normal progress through mitosis and normal proliferation of hepatocytes after partial hepatectomy. Mediates responses to ischemia and hypoxia; regulates the expression of proteins such as IL1B and CXCL2 that are involved in inflammatory processes and development of tissue damage after ischemia. Regulates biosynthesis of luteinizing hormone (LHB) in the pituitary (By similarity).
Cellular Localization Nucleus Cytoplasm
Tissue Specificity Detected in neutrophils (at protein level).
Sequence and Domain Family Binds to DNA motifs with the sequence 5'-GCG(T/G)GGGCG-3' via its C2H2-type zinc fingers . The first, most N-terminal zinc finger binds to the 3'-GCG motif, the middle zinc finger interacts with the central TGG motif, and the C-terminal zinc finger binds to the 5'-GCG motif. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Has reduced affinity for target DNA where the cytosines have been oxidized to 5-hydroxymethylcytosine. Does not bind target DNA where the cytosines have been oxidized to 5-formylcytosine or 5-carboxylcytosine .

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