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Anti-Endophilin I antibody

[STJ92924] Download PDF Print Data Sheet
Anti-Endophilin I antibody

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Product name Anti-Endophilin I antibody
Short Description Rabbit Polyclonal to Endophilin I.
Description Endophilin I is a protein encoded by the SH3GL2 gene which is approximately 39,9 kDa. Endophilin I is localised to the cytoplasm and cell membrane. It is involved in clathrin derived vesicle budding, RET signalling and developmental biology. It function is in synaptic vesicle endocytosis. Endophilin I is expressed in the brain, mostly in the frontal cortex. Mutations in the SH3GL2 gene may result in childhood Pilocytic Astrocytoma. STJ92924 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Endophilin I protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000 / ELISA 1:10000 /
Specificity Endophilin I Polyclonal Antibody detects endogenous levels of Endophilin I protein.
Protein Name Endophilin-A1 - SH3GL2 - SH3P4 - SH3D2A - CNSA2 - EEN-B1 - SH3 domain containing GRB2 like 2 - endophilin A1
Immunogen Synthesized peptide derived from human Endophilin I
Immunogen Region 30-110 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6456 (Human) / 20404 (Mouse) / 116743 (Rat)
Gene Symbol SH3GL2
Molecular Weight 39 kDa
Database Links Human UniProt/Swiss-Prot:Q99962 Mouse UniPort/Swiss-Prot: Q62420 Rat UniProt/Swiss-Port: O35179 Human Entrez Gene: 6456 Mouse Entrez Gene: 20404 Rat Entrez Gene: Rn.10787
Alternative Names SH3GL2 / SH3 domain containing GRB2 like 2 / A306_01431 antibody / AS27_10746 antibody / AS28_10893 antibody / bA335L15.1 (SH3-domain GRB2-like 2) antibody / CB1_000478030 antibody / CNSA2 antibody / D623_10027294 antibody / EEN-B1 antibody / endophilin-1 antibody / endophilin A1 antibody / endophilin-A1 antibody / Endophilin A1 BAR domain antibody / endophilin-A1-like protein antibody / endophilin I antibody / GW7_18987 antibody / H920_08138 antibody / hypothetical protein antibody / I79_011505 antibody / M91_00261 antibody / M959_10117 antibody / MDA_GLEAN10017398 antibody / N300_15508 antibody / N301_04643 antibody / N302_15906 antibody / N303_15414 antibody / N305_10251 antibody / N306_09703 antibody / N307_14387 antibody / N308_12628 antibody / N309_09360 antibody / N310_01615 antibody / N311_02915 antibody / N312_03286 antibody / N320_11066 antibody / N321_01299 antibody / N322_07598 antibody / N325_00409 antibody / N326_08272 antibody / N327_02829 antibody / N328_10891 antibody / N329_02954 antibody / N330_06120 antibody / N331_09841 antibody / N332_09830 antibody / N334_03021 antibody / N335_02630 antibody / N336_05773 antibody / N339_00945 antibody / N340_04128 antibody / N341_03720 antibody / PAL_GLEAN10021008 antibody / PANDA_009546 antibody / SH3D2A antibody / SH3 domain-containing GRB2-like protein 1 antibody / SH3 domain-containing GRB2-like protein 2 antibody / SH3-domain GRB2-like 2 antibody / SH3 domain protein 2A antibody / SH3p4 antibody / SH3PA antibody / TREES_T100021337 antibody / Y1Q_000456 antibody / Y956_08179 antibody / Z169_03381 antibody
Function Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Cellular Localization Cytoplasm Membrane Early endosome Note=Concentrated in presynaptic nerve terminals in neurons.
Tissue Specificity Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum.
Sequence and Domain Family An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface.

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