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Anti-GFAP antibody

[STJ96961] Download PDF Print Data Sheet

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Product name Anti-GFAP antibody
Short Description Mouse Monoclonal to GFAP.
Description GFAP is a protein encoded by the GFAP gene which is approximately 49,8 kDa. GFAP is localised to the cytoplasm. It is involved in signalling by ERBB4, the Jak-STAT signalling pathway, neural stem cell differentiation pathways, lineage-specific markers and ERK signalling. It is one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. GFAP is expressed in the cells of the nervous system, kidney, blood, eye and heart. Mutations in the GFAP gene may result in Alexandra disease. STJ96961 was developed from clone 5C8 and was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. This primary antibody binds endogenous GFAP.
Applications WB
Dilution range WB 1:2000-5000
Specificity The antibody detects endogenous GFAP proteins.
Protein Name Glial fibrillary acidic protein - GFAP - FLJ45472 - glial fibrillary acidic protein
Immunogen Synthetic Peptide
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 5C8
Reactivity Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 2670 (Human) / 14580 (Mouse) / 24387 (Rat)
Gene Symbol GFAP
Database Links Human UniProt/Swiss-Prot:P14136 Mouse UniPort/Swiss-Prot: P03995 Rat UniProt/Swiss-Port: P47819 Human Entrez Gene: 2670 Mouse Entrez Gene: 14580 Rat Entrez Gene: Rn.91512
Alternative Names GFAP / glial fibrillary acidic protein / A306_07395 antibody / ALXDRD antibody / CB1_000085010 antibody / D623_10009505 antibody / etID36982.3 antibody / gfapl antibody / glial fibrillary acidic protein alpha antibody / glial fibrillary acidic protein delta antibody / GW7_01564 antibody / H920_13336 antibody / hypothetical protein antibody / I79_011607 antibody / intermediate filament antibody / intermediate filament protein antibody / N302_11388 antibody / N305_14193 antibody / N308_15470 antibody / N334_05804 antibody / PAL_GLEAN10004257 antibody / PANDA_008470 antibody / TREES_T100006001 antibody / UY3_01344 antibody / VIM antibody / vimentin antibody / xx:af506734 antibody / Y1Q_000360 antibody / Y956_08240 antibody / zrf-1 antigen antibody
Function GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.
Post-translational Modifications Phosphorylated by PKN1.
Cellular Localization Cytoplasm Note=Associated with intermediate filaments.
Tissue Specificity Expressed in cells lacking fibronectin.

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