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Anti-HSP60 antibody

[STJ93621] Download PDF Print Data Sheet

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Product name Anti-HSP60 antibody
Short Description Rabbit Polyclonal to HSP60.
Description HSP60 is a protein encoded by the HSPD1 gene which is approximately 61 kDa. HSP60 is localised to the mitochondrion matrix and is involved in gene expression, transcriptional regulation, legionellosis and deadenylation-dependent mRNA decay. This protein falls under the chaperonin family. It is essential for the folding and assembly of newly imported proteins in the mitochondria. It also prevents misfolding and promote the refolding of unfolded polypeptides generated under stress conditions in the mitochondrial matrix. HSP60 is expressed in liver, nervous system, blood, lung and skin. Mutations in the HSPD1 gene result in spastic paraplegia and leukodystrophy. STJ93621 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of HSP60 protein.
Applications IHC-p, ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:10000 /
Specificity HSP60 Polyclonal Antibody detects endogenous levels of HSP60 protein.
Protein Name 60 kDa heat shock protein mitochondrial - HSPD1 - GroEL - HSP60 - SPG13 - heat shock protein family D (Hsp60) member 1
Immunogen Synthesized peptide derived from human HSP60
Immunogen Region 480-560 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3329 (Human) / 15510 (Mouse) / 63868 (Rat)
Gene Symbol HSPD1
Molecular Weight 68 kDa
Database Links Human UniProt/Swiss-Prot:P10809 Mouse UniPort/Swiss-Prot: P63038 Rat UniProt/Swiss-Port: P63039 Human Entrez Gene: 3329 Mouse Entrez Gene: 15510 Rat Entrez Gene: Rn.102058
Alternative Names HSPD1 / heat shock protein family D (Hsp60) member 1 / 60kDa antibody / 60 kDa chaperonin antibody / 60 kDa heat shock protein antibody / 60 kDa heat shock protein / mitochondrial antibody / A306_02014 antibody / Anapl_04561 antibody / AS27_04091 antibody / AS28_03220 antibody / CB1_000195003 antibody / chaperonin antibody / Chaperonin 60 antibody / CPN60 antibody / D623_10019963 antibody / fa04a05 antibody / fb22d10 antibody / fi27b05 antibody / groel antibody / H920_08605 antibody / heat shock 60 kDa protein 1 antibody / heat shock 60kDa protein 1 antibody / heat shock 60kDa protein 1 (chaperonin) antibody / heat shock 60kD protein 1 (chaperonin) antibody / heat shock 60 protein 1 antibody / heat shock protein antibody / heat shock protein 1 (chaperonin) antibody / Heat shock protein 60 antibody / heat shock protein / 60 kDa antibody / heat shock protein 60 (liver) antibody / heat shock protein 65 antibody / heat shock protein family D member 1 antibody / heat shock protein / mitochondrial precursor (Hsp60) isoform 4-like protein antibody / HLD4 antibody / HSP60 antibody / HSP-60 antibody / HSP65 antibody / HSP-65 antibody / Hspd1-30p antibody / HuCHA60 antibody / hypothetical protein antibody / I79_011398 antibody / M959_04870 antibody / MDA_GLEAN10023680 antibody / mitochondrial 60 kDa heat shock protein-like protein antibody / mitochondrial heat shock 60 kDa protein 1 antibody / mitochondrial matrix protein P1 antibody / N300_06727 antibody / N301_02433 antibody / N302_09814 antibody / N306_13046 antibody / N307_08532 antibody / N308_02973 antibody / N309_02086 antibody / N311_07171 antibody / N312_07164 antibody / N320_09479 antibody / N321_13520 antibody / N324_06229 antibody / N325_10190 antibody / N326_00221 antibody / N327_02245 antibody / N328_12149 antibody / N329_02884 antibody / N330_09286 antibody / N331_00481 antibody / N332_12023 antibody / N333_09877 antibody / N335_12209 antibody / N339_11116 antibody / N340_11072 antibody / N341_08765 antibody / nbl antibody / no blastema antibody / P1 protein antibody / P60 lymphocyte protein antibody / PAL_GLEAN10026090 antibody / short heat shock protein 60 Hsp60s1 antibody / SPG13 antibody / TREES_T100015018 antibody / UY3_18595 antibody / Y1Q_010182 antibody / Y956_07499 antibody / Z169_07044 antibody
Function Chaperonin implicated in mitochondrial protein import and macromolecular assembly. Together with Hsp10, facilitates the correct folding of imported proteins. May also prevent misfolding and promote the refolding and proper assembly of unfolded polypeptides generated under stress conditions in the mitochondrial matrix . The functional units of these chaperonins consist of heptameric rings of the large subunit Hsp60, which function as a back-to-back double ring. In a cyclic reaction, Hsp60 ring complexes bind one unfolded substrate protein per ring, followed by the binding of ATP and association with 2 heptameric rings of the co-chaperonin Hsp10. This leads to sequestration of the substrate protein in the inner cavity of Hsp60 where, for a certain period of time, it can fold undisturbed by other cell components. Synchronous hydrolysis of ATP in all Hsp60 subunits results in the dissociation of the chaperonin rings and the release of ADP and the folded substrate protein (Probable).
Cellular Localization Mitochondrion matrix.

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