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Anti-Inhibin β-A antibody

[STJ96774] Download PDF Print Data Sheet
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Product name Anti-Inhibin β-A antibody
Short Description Rabbit polyclonal to Inhibin β-A.
Description Inhibin beta-A is a protein encoded by the INHBA gene which is approximately 47,4 kDa. Inhibin beta-A is secreted and is involved in the peptide hormone metabolism, signalling by NODAL, PEDF induced signalling, signalling pathways regulating pluripotency of stem cells and TGF-beta signalling pathway. This protein falls under the TGF-beta superfamily. Inhibins beta-A is involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation and also plays a role in eye, tooth and testis development. Inhibin beta-A is expressed in the eyes. Mutations in the INHBA gene may result in ovary adenocarcinoma and myasthenic syndrome. STJ96774 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope specific immunogen. This polyclonal antibody detects endogenous levels of Inhibin beta-A protein.
Applications ELISA, ICC, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC-P 1:100-1:300
ELISA 1:20000
Specificity Inhibin β-A Polyclonal Antibody detects endogenous levels of Inhibin β-A protein.
Protein Name Inhibin beta A chain
Activin beta-A chain
Erythroid differentiation protein
EDF
Immunogen Synthesized peptide derived from human Inhibin β-A.
Immunogen Region 371-420 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3624
Gene Symbol INHBA
Molecular Weight 52 kDa
Database Links HGNC:6066
OMIM:147290
Alternative Names Anti-Inhibin ß-A antibody
Function Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.
Cellular Localization Secreted.
Swiss-Prot Key P08476_HUMAN
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