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Anti-Jagged1 antibody

[STJ96766] Download PDF Print Data Sheet

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Product name Anti-Jagged1 antibody
Short Description Rabbit Polyclonal to Jagged1.
Description Jagged1 is a protein encoded by the JAG1 gene which is approximately 133,7 kDa. Jagged1 is localised to the plasma membrane. It is involved in signalling by Notch1, Notch2 activation and transmission of signal to the nucleus and the HIV life cycle. It is a ligand for multiple Notch receptors and may also be involved in cell-fate decisions during hematopoiesis and in the early and late stages of mammalian cardiovascular development. Jagged1 is widely expressed in adult and foetal tissues. Mutations in the JAG1 gene may result in Alagille syndrome. STJ96766 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Jagged1 protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC-P 1:100-1:300 / ELISA 1:20000 /
Specificity Jagged1 Polyclonal Antibody detects endogenous levels of Jagged1 protein.
Protein Name Protein jagged-1 - JAG1 - AHD - AWS - HJ1 - CD339 - AGS - JAGL1 - jagged 1
Immunogen Synthesized peptide derived from human Jagged1.
Immunogen Region 981-1030 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 182 (Human) / 16449 (Mouse) / 29146 (Rat)
Gene Symbol JAG1
Molecular Weight 140 kDa
Database Links Human UniProt/Swiss-Prot:P78504 Mouse UniPort/Swiss-Prot: Q9QXX0 Rat UniProt/Swiss-Port: Q63722 Human Entrez Gene: 182 Mouse Entrez Gene: 16449 Rat Entrez Gene: Rn.88804
Alternative Names JAG1 / jagged 1 / A306_10556 antibody / ABE2 antibody / AGS antibody / AHD antibody / AS27_11330 antibody / AS28_01662 antibody / AWS antibody / CB1_000951001 antibody / CD339 antibody / C-Serate-1 protein antibody / D623_10032291 antibody / Gsfabe2 antibody / GW7_07255 antibody / H920_09536 antibody / HJ1 antibody / Htu antibody / hypothetical protein antibody / I79_000425 antibody / jagged1 antibody / jagged 1 (Alagille syndrome) antibody / Jagged-1 precursor isoform 3-like protein antibody / JAGL1 antibody / M91_15231 antibody / M959_07824 antibody / MDA_GLEAN10025066 antibody / N300_06370 antibody / N301_10998 antibody / N302_14352 antibody / N305_03536 antibody / N306_06619 antibody / N307_05877 antibody / N308_11928 antibody / N309_08113 antibody / N310_02520 antibody / N311_00701 antibody / N312_06046 antibody / N322_01082 antibody / N325_11791 antibody / N326_06045 antibody / N327_05149 antibody / N328_06301 antibody / N330_14535 antibody / N331_02636 antibody / N332_11228 antibody / N333_08213 antibody / N334_04221 antibody / N335_13280 antibody / N339_08777 antibody / N340_02557 antibody / Ozz antibody / PAL_GLEAN10024058 antibody / PANDA_007300 antibody / Protein jagged-1 antibody / Ser-1 antibody / serrate antibody / serrate-1 antibody / TREES_T100009915 antibody / UY3_11127 antibody / x-serrate-1 antibody / Y1Q_030215 antibody / Y956_14546 antibody / Z169_10201 antibody
Function Ligand for multiple Notch receptors and involved in the mediation of Notch signaling. May be involved in cell-fate decisions during hematopoiesis. Seems to be involved in early and late stages of mammalian cardiovascular development. Inhibits myoblast differentiation (By similarity). Enhances fibroblast growth factor-induced angiogenesis (in vitro).
Cellular Localization Membrane; Single-pass type I membrane protein.
Tissue Specificity Widely expressed in adult and fetal tissues. In cervix epithelium expressed in undifferentiated subcolumnar reserve cells and squamous metaplasia. Expression is up-regulated in cervical squamous cell carcinoma. Expressed in bone marrow cell line HS-27a wh
Sequence and Domain Family The second EGF-like domain is atypical.

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