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Anti-Lamin B1 antibody

[STJ96938] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Lamin B1 antibody
Short Description Mouse Monoclonal to Lamin B1.
Description Lamin B1 is a protein encoded by the LMNB1 gene which is approximately 66,4 kDa. Lamin B1 is localised to the nuclear inner membrane. It is involved in the apoptosis and survival caspase cascade , mitotic cell cycle, granzyme pathway and CDK-mediated phosphorylatin. It is one of the two B-type lamin proteins and is a component of the nuclear lamina. It is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin B1 is expressed in the liver, nervous system, eye, heart and intestine. Mutations in the LMNB1 gene result in autosomal dominant, adult-onset leukodystrophy. STJ96938 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Lamin B1 protein.
Applications IP, WB
Dilution range WB 1:2000-5000
IP 1:200
Specificity The antibody detects endogenous Lamin B1 protein.
Protein Name Lamin-B1
Immunogen Recombinant Protein
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 7C11
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4001
Gene Symbol LMNB1
Database Links HGNC:6637
OMIM:150340
Alternative Names LMNB1 antibody
LMN2 antibody
LMNB antibody
Lamin-B1 antibody
Function Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Post-translational Modifications B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Cellular Localization Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.
Swiss-Prot Key P20700_HUMAN
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1
I am interested in this antibody in 0.3mg size, 1mg/mL. Would it be possible to change the storage buffer to PBS and not include sodium azide?
Question by: Guest on 11 Apr 2018 13:40:00
-3
Hello, thank you for your query. If you would like to place a custom order, the product should be at least 1 mg. There will be no additional cost for changing the storage buffer. Please contact us at info@stjohnslabs.com for further information.
Answer by: Customer Support on 11 Apr 2018 13:43:00

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