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Anti-Lamin B1 antibody

[STJ96938] Download PDF Print Data Sheet

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Product name Anti-Lamin B1 antibody
Short Description Mouse Monoclonal to Lamin B1.
Description Lamin B1 is a protein encoded by the LMNB1 gene which is approximately 66,4 kDa. Lamin B1 is localised to the nuclear inner membrane. It is involved in the apoptosis and survival caspase cascade , mitotic cell cycle, granzyme pathway and CDK-mediated phosphorylatin. It is one of the two B-type lamin proteins and is a component of the nuclear lamina. It is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin B1 is expressed in the liver, nervous system, eye, heart and intestine. Mutations in the LMNB1 gene result in autosomal dominant, adult-onset leukodystrophy. STJ96938 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Lamin B1 protein.
Applications IP, WB
Dilution range WB 1:2000-5000 / IP 1:200
Specificity The antibody detects endogenous Lamin B1 protein.
Protein Name Lamin-B1 - LMNB1 - lamin B1
Immunogen Recombinant Protein
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 7C11
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4001 (Human) / 16906 (Mouse) / 116685 (Rat)
Gene Symbol LMNB1
Database Links Human UniProt/Swiss-Prot:P20700 Mouse UniPort/Swiss-Prot: P14733 Rat UniProt/Swiss-Port: P70615 Human Entrez Gene: 4001 Mouse Entrez Gene: 16906 Rat Entrez Gene: Rn.11362
Alternative Names LMNB1 / lamin B1 / ADLD antibody / Anapl_17995 antibody / AS27_09747 antibody / AS28_00834 antibody / CB1_001532012 antibody / fc06g01 antibody / H920_06602 antibody / hypothetical protein antibody / I79_003938 antibody / lamin b antibody / lamin-b antibody / Lamin-B1 antibody / Lamin-B1-like protein antibody / Lamin-L(I) antibody / LMN antibody / lmn2 antibody / LMNB antibody / M91_03375 antibody / M959_02951 antibody / MDA_GLEAN10020664 antibody / N301_09389 antibody / N302_08926 antibody / N303_06544 antibody / N305_03236 antibody / N306_01916 antibody / N309_14235 antibody / N324_00503 antibody / N328_07823 antibody / N329_09369 antibody / N333_00556 antibody / N334_06646 antibody / N336_05195 antibody / N339_03548 antibody / PAL_GLEAN10025103 antibody / PANDA_006526 antibody / Y1Q_027424 antibody / Y956_06020 antibody
Function Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Post-translational Modifications B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Cellular Localization Nucleus inner membrane; Lipid-anchor; Nucleoplasmic side.


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