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Anti-LC3A antibody

[STJ97755] Download PDF Print Data Sheet

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Product name Anti-LC3A antibody
Description Mouse Monoclonal to LC3A.
Host Mouse
Reactivity Human, Mouse, Rat
Applications IHC, WB
Immunogen synthetic peptide derived from LC3A
Gene ID 84557 (Human)
Dilution range WB 1:1000-2000 / IHC 1:100-200
Specificity LC3A Mouse Monoclonal Antibody (5G10) detects endogenous levels of LC3A
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Clone ID 5G10
Note For Research Use Only (RUO).
Protein Name LC3A - MAP1LC3A - MAP1BLC3 - MAP1ALC3 - LC3 - LC3A - ATG8E - microtubule associated protein 1 light chain 3 alpha
Clonality Monoclonal
Conjugation Unconjugated
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Concentration 1 mg/ml
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Database Links Human UniProt/Swiss-Prot:Q9H492 Mouse UniPort/Swiss-Prot: Q91VR7 Rat UniProt/Swiss-Port: Q6XVN8 Human Entrez Gene: 84557 Mouse Entrez Gene: 66734 Rat Entrez Gene: Rn.3135
Alternative Names MAP1LC3A / microtubule associated protein 1 light chain 3 alpha / A306_15561 antibody / Anapl_11015 antibody / AS27_08286 antibody / AS28_13658 antibody / ATG8E antibody / autophagy-related protein LC3 A antibody / autophagy-related ubiquitin-like modifier LC3 A antibody / CB1_001108010 antibody / D623_10023711 antibody / hypothetical protein antibody / LC3 antibody / LC3a antibody / M91_20166 antibody / MAP1A /1B light chain 3 A antibody / map1alc3 antibody / MAP1A /MAP1B LC3 A antibody / MAP1A /MAP1B light chain 3 A antibody / MAP1BLC3 antibody / MAP1 light chain 3-like protein 1 antibody / MDA_GLEAN10022767 antibody / microtubule-associated protein 1-light chain 3A antibody / microtubule-associated protein 1 light chain 3 alpha antibody / microtubule-associated proteins 1A /1B light chain 3 antibody / microtubule-associated proteins 1A /1B light chain 3A antibody / MLP3A antibody / N300_03309 antibody / N301_10046 antibody / N302_10607 antibody / N303_01433 antibody / N305_10924 antibody / N306_12760 antibody / N307_02577 antibody / N308_12185 antibody / N309_03482 antibody / N310_07644 antibody / N311_12727 antibody / N320_06026 antibody / N322_02067 antibody / N324_03118 antibody / N325_03585 antibody / N329_09743 antibody / N330_01429 antibody / N331_04235 antibody / N333_05527 antibody / N334_07672 antibody / N335_05660 antibody / N336_09666 antibody / N339_08320 antibody / PAL_GLEAN10024250 antibody / PANDA_004515 antibody / putative microtubule-associated protein 1 light chain 3 alpha antibody / TREES_T100008638 antibody / Y1Q_020976 antibody / Y956_05596 antibody / Z169_05259 antibody
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation .
Post-translational Modifications The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II . ; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine. ; Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
Cellular Localization Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome Note=LC3-II binds to the autophagic membranes.

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