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Anti-LC3A antibody

[STJ97755] Download PDF Print Data Sheet

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Product name Anti-LC3A antibody
Short Description Mouse Monoclonal to LC3A.
Description LC3A is a protein encoded by the MAP1LC3A gene which is approximately 14,3 kD. LC3A is localised to the cytoplasm, cytoskeleton and autophagosome. It is involved in pathways such as the autophagy pathway, pink/parkin mediated mitophagy, ferroptosis, cellular senescence and pathways affecting insulin-like growth factor-Akt signalling. MAP1A and MAP1B fall under the LC3A protein. They are microtubule-associated proteins that mediate the physical interactions between microtubules and components of the cytoskeleton. LC3A is most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes. Mutations in the LC3A gene may result in Nasu-Hakola disease , lacrimal gland adenocarcinoma and leber congenital amaurosis. STJ97755 was developed from clone 5G10. It was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. The antibody detects endogenous levels of LC3A.
Applications IHC-p, WB
Dilution range WB 1:1000-2000 / IHC 1:100-200
Specificity LC3A Mouse Monoclonal Antibody (5G10) detects endogenous levels of LC3A
Protein Name LC3A - MAP1LC3A - MAP1BLC3 - MAP1ALC3 - LC3 - LC3A - ATG8E - microtubule associated protein 1 light chain 3 alpha
Immunogen synthetic peptide derived from LC3A
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Mouse
Clonality Monoclonal
Clone ID 5G10
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
Isotype IgG1
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 84557 (Human)
Gene Symbol MAP1LC3A
Database Links Human UniProt/Swiss-Prot:Q9H492 Mouse UniPort/Swiss-Prot: Q91VR7 Rat UniProt/Swiss-Port: Q6XVN8 Human Entrez Gene: 84557 Mouse Entrez Gene: 66734 Rat Entrez Gene: Rn.3135
Alternative Names MAP1LC3A / microtubule associated protein 1 light chain 3 alpha / A306_15561 antibody / Anapl_11015 antibody / AS27_08286 antibody / AS28_13658 antibody / ATG8E antibody / autophagy-related protein LC3 A antibody / autophagy-related ubiquitin-like modifier LC3 A antibody / CB1_001108010 antibody / D623_10023711 antibody / hypothetical protein antibody / LC3 antibody / LC3a antibody / M91_20166 antibody / MAP1A /1B light chain 3 A antibody / map1alc3 antibody / MAP1A /MAP1B LC3 A antibody / MAP1A /MAP1B light chain 3 A antibody / MAP1BLC3 antibody / MAP1 light chain 3-like protein 1 antibody / MDA_GLEAN10022767 antibody / microtubule-associated protein 1-light chain 3A antibody / microtubule-associated protein 1 light chain 3 alpha antibody / microtubule-associated proteins 1A /1B light chain 3 antibody / microtubule-associated proteins 1A /1B light chain 3A antibody / MLP3A antibody / N300_03309 antibody / N301_10046 antibody / N302_10607 antibody / N303_01433 antibody / N305_10924 antibody / N306_12760 antibody / N307_02577 antibody / N308_12185 antibody / N309_03482 antibody / N310_07644 antibody / N311_12727 antibody / N320_06026 antibody / N322_02067 antibody / N324_03118 antibody / N325_03585 antibody / N329_09743 antibody / N330_01429 antibody / N331_04235 antibody / N333_05527 antibody / N334_07672 antibody / N335_05660 antibody / N336_09666 antibody / N339_08320 antibody / PAL_GLEAN10024250 antibody / PANDA_004515 antibody / putative microtubule-associated protein 1 light chain 3 alpha antibody / TREES_T100008638 antibody / Y1Q_020976 antibody / Y956_05596 antibody / Z169_05259 antibody
Function Ubiquitin-like modifier involved in formation of autophagosomal vacuoles (autophagosomes) . Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation .
Post-translational Modifications The precursor molecule is cleaved by ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II . ; The Legionella effector RavZ is a deconjugating enzyme that produces an ATG8 product that would be resistant to reconjugation by the host machinery due to the cleavage of the reactive C-terminal glycine. ; Phosphorylation at Ser-12 by PKA inhibits conjugation to phosphatidylethanolamine (PE). Interaction with MAPK15 reduces the inhibitory phosphorylation and increases autophagy activity.
Cellular Localization Cytoplasm, cytoskeleton. Endomembrane system; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome Note=LC3-II binds to the autophagic membranes.
Tissue Specificity Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.

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