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Anti-Mcl-1 antibody

[STJ94044] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Mcl-1 antibody
Short Description Rabbit polyclonal to Mcl-1.
Description Mcl-1 is a protein encoded by the MCL1 gene which is approximately 37,3 kDa. Mcl-1 is localised to the cell membrane, cytoplasm, mitochondrion and nucleus. It is involved in apoptosis modulation and signalling, the Jak-STAT signalling pathway, cytokine signalling in the immune system and the PI3K-Akt signalling pathway. It regulated of apoptosis and cell survival, and plays a role in the maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes apoptosis. Mcl-1 is expressed in the nervous system, blood, lung, bone marrow and liver. Mutations in the MCL1 gene may result in myeloid leukaemia and follicular lymphoma. STJ94044 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Mcl-1 protein.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Specificity Mcl-1 Polyclonal Antibody detects endogenous levels of Mcl-1 protein.
Protein Name Induced myeloid leukemia cell differentiation protein Mcl-1
Bcl-2-like protein 3
Bcl2-L-3
Bcl-2-related protein EAT/mcl1
mcl1/EAT
Immunogen Synthesized peptide derived from human Mcl-1
Immunogen Region 60-140 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4170
Gene Symbol MCL1
Molecular Weight 37 kDa
Database Links HGNC:6943
OMIM:159552
Alternative Names Anti-Mcl-1 antibody
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Post-translational Modifications Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.; Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
Cellular Localization Membrane Cytoplasm. Mitochondrion. Nucleus, nucleoplasm.. Cytoplasmic, associated with mitochondria.
Swiss-Prot Key Q07820_HUMAN
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