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Anti-Mcl-1 antibody

[STJ94044] Download PDF Print Data Sheet

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Product name Anti-Mcl-1 antibody
Short Description Rabbit Polyclonal to Mcl-1.
Description Mcl-1 is a protein encoded by the MCL1 gene which is approximately 37,3 kDa. Mcl-1 is localised to the cell membrane, cytoplasm, mitochondrion and nucleus. It is involved in apoptosis modulation and signalling, the Jak-STAT signalling pathway, cytokine signalling in the immune system and the PI3K-Akt signalling pathway. It regulated of apoptosis and cell survival, and plays a role in the maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes apoptosis. Mcl-1 is expressed in the nervous system, blood, lung, bone marrow and liver. Mutations in the MCL1 gene may result in myeloid leukaemia and follicular lymphoma. STJ94044 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Mcl-1 protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:40000 /
Specificity Mcl-1 Polyclonal Antibody detects endogenous levels of Mcl-1 protein.
Protein Name Induced myeloid leukemia cell differentiation protein Mcl-1 - MCL1 - BCL2L3 - Mcl-1 - MCL1 - BCL2 family apoptosis regulator
Immunogen Synthesized peptide derived from human Mcl-1
Immunogen Region 60-140 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4170 (Human) / 17210 (Mouse) / 60430 (Rat)
Gene Symbol MCL1
Molecular Weight 37 kDa
Database Links Human UniProt/Swiss-Prot:Q07820 Mouse UniPort/Swiss-Prot: P97287 Rat UniProt/Swiss-Port: Q9Z1P3 Human Entrez Gene: 4170 Mouse Entrez Gene: 17210 Rat Entrez Gene: Rn.129914
Alternative Names MCL1 / myeloid cell leukemia 1 / A306_00560 antibody / Anapl_16713 antibody / AS27_10015 antibody / AS28_04112 antibody / bcl2l3 antibody / bcl2-L-3 antibody / bcl-2-like protein 3 antibody / Bcl-2-related protein antibody / bcl-2-related protein EAT /mcl1 antibody / CB1_000914022 antibody / D623_10031842 antibody / EAT antibody / H920_20395 antibody / I79_004573 antibody / induced myeloid leukemia cell differentiation protein Mcl-1 antibody / induced myeloid leukemia cell differentiation protein Mcl-1 homolog antibody / Induced myeloid leukemia cell differentiation protein Mcl-1-like antibody / induced myeloid leukemia cell differentiation protein Mcl-1-like protein antibody / Induced myeloid leukemia cell differentiation protein Mcl-1 like protein antibody / leukocyte receptor cluster member 8 homolog antibody / M959_06315 antibody / Mcl-1 antibody / mcl1 /EAT antibody / MCL1-ES antibody / MCL1L antibody / MCL1S antibody / myeloid cell leukemia ES antibody / myeloid cell leukemia protein 1 antibody / myeloid cell leukemia protein MCL-1 antibody / myeloid cell leukemia sequence 1 antibody / myeloid cell leukemia sequence 1 (BCL2-related) antibody / N300_14636 antibody / N301_16340 antibody / N302_02146 antibody / N303_11529 antibody / N306_01451 antibody / N308_01430 antibody / N309_14198 antibody / N310_05580 antibody / N312_05448 antibody / N320_04714 antibody / N321_06031 antibody / N322_07291 antibody / N326_02303 antibody / N327_06650 antibody / N328_05341 antibody / N329_03008 antibody / N330_06124 antibody / N331_04165 antibody / N332_08968 antibody / N333_07323 antibody / N334_05355 antibody / N335_05294 antibody / N336_06496 antibody / N339_05826 antibody / N340_09542 antibody / N341_08351 antibody / PAL_GLEAN10017542 antibody / TM antibody / TREES_T100021289 antibody / Y1Q_015199 antibody / Y956_15304 antibody / Z169_02046 antibody
Function Involved in the regulation of apoptosis versus cell survival, and in the maintenance of viability but not of proliferation. Mediates its effects by interactions with a number of other regulators of apoptosis. Isoform 1 inhibits apoptosis. Isoform 2 promotes apoptosis.
Post-translational Modifications Cleaved by CASP3 during apoptosis. In intact cells cleavage occurs preferentially after Asp-127, yielding a pro-apoptotic 28 kDa C-terminal fragment.; Rapidly degraded in the absence of phosphorylation on Thr-163 in the PEST region. ; Phosphorylated on Ser-159, by GSK3, in response to IL3/interleukin-3 withdrawal. Phosphorylation at Ser-159 induces ubiquitination and proteasomal degradation, abrogating the anti-apoptotic activity. Treatment with taxol or okadaic acid induces phosphorylation on additional sites. ; Ubiquitinated. Ubiquitination is induced by phosphorylation at Ser-159.
Cellular Localization Membrane Cytoplasm. Mitochondrion. Nucleus, nucleoplasm. Note=Cytoplasmic, associated with mitochondria.

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