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Anti-Met antibody

[STJ94103] Download PDF Print Data Sheet

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Product name Anti-Met antibody
Short Description Rabbit Polyclonal to Met.
Description Rabbit Polyclonal to Met.
Applications ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IF 1:200-1:1000 / ELISA 1:10000 /
Specificity Met Polyclonal Antibody detects endogenous levels of Met protein.
Protein Name Hepatocyte growth factor receptor - MET - HGFR - RCCP2 - DFNB97 - MET proto-oncogene - receptor tyrosine kinase
Immunogen Synthesized peptide derived from human Met around the non-phosphorylation site of Y1349.
Immunogen Region 1290-1370 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4233 (Human) / 24553 (Rat)
Gene Symbol MET
Molecular Weight 145 kDa
Database Links Human UniProt/Swiss-Prot:P08581 Rat UniProt/Swiss-Port: P97523 Human Entrez Gene: 4233 Mouse Entrez Gene: 17295 Rat Entrez Gene: Rn.10617
Alternative Names MET / MET proto-oncogene / receptor tyrosine kinase / AS27_03512 antibody / AS28_05696 antibody / AUTS9 antibody / bHLHe59 antibody / CB1_000316005 antibody / CG1705-PA antibody / CG1705-PB antibody / cmet antibody / C-MET antibody / c-met /hepatocyte growth factor receptor antibody / D623_10018982 antibody / DFNB97 antibody / Dmel_CG1705 antibody / DmMet antibody / EGK_14061 antibody / growth factor receptor c-met antibody / H920_04322 antibody / hepatocyte growth factor receptor antibody / hepatocyte growth factor receptor-like protein antibody / HGF antibody / Hgfr antibody / HGF receptor antibody / HGF receptor c-Met antibody / HGF /SF receptor antibody / hypothetical protein antibody / I79_007063 antibody / juvenile hormone resistance antibody / M91_16200 antibody / M959_12840 antibody / macrophage stimulating 1 receptor (c-met-related tyrosine kinase) antibody / MDA_GLEAN10003316 antibody / met-A antibody / methoprene tolerant antibody / methoprene-tolerant antibody / Methoprene-tolerant protein antibody / Met /Met1 antibody / Met-PA antibody / Met-PB antibody / met proto-oncogene antibody / met proto-oncogene (hepatocyte growth factor receptor) antibody / met proto-oncogene tyrosine kinase antibody / met proto-oncoprotein antibody / Mett antibody / MST1R antibody / N301_16372 antibody / N303_08951 antibody / N306_00647 antibody / N307_04073 antibody / N308_04918 antibody / N309_11121 antibody / N310_11515 antibody / N311_00724 antibody / N312_13765 antibody / N321_03402 antibody / N322_00507 antibody / N324_02555 antibody / N326_04052 antibody / N327_08710 antibody / N328_11582 antibody / N329_03899 antibody / N330_02675 antibody / N331_08779 antibody / N332_10590 antibody / N333_13326 antibody / N334_05625 antibody / N335_02210 antibody / N336_12651 antibody / N339_09042 antibody / N340_00938 antibody / N341_12072 antibody / OSFD antibody / PAL_GLEAN10019217 antibody / PANDA_005689 antibody / Par4 antibody / proto-oncogene c-Met antibody / proto-oncogene / receptor tyrosine kinase antibody / RCCP2 antibody / resistance (1) juvenile H antibody / resistance to juvenile hormone antibody / Rst(1)JH antibody / Scatter factor receptor antibody / SF receptor antibody / soluble MET variant 12 antibody / TREES_T100021969 antibody / tyrosine kinase antibody / tyrosine-protein kinase Met antibody / Y1Q_003488 antibody / Z169_03161 antibody
Function Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand. Regulates many physiological processes including proliferation, scattering, morphogenesis and survival. Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1. Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects. During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation. In adults, participates in wound healing as well as organ regeneration and tissue remodeling. Promotes also differentiation and proliferation of hematopoietic cells. May regulate cortical bone osteogenesis (By similarity). ; Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells.
Post-translational Modifications Autophosphorylated in response to ligand binding on Tyr-1234 and Tyr-1235 in the kinase domain leading to further phosphorylation of Tyr-1349 and Tyr-1356 in the C-terminal multifunctional docking site. Dephosphorylated by PTPRJ at Tyr-1349 and Tyr-1365. Dephosphorylated by PTPN1 and PTPN2. ; Ubiquitinated. Ubiquitination by CBL regulates MET endocytosis, resulting in decreasing plasma membrane receptor abundance, and in endosomal degradation and/or recycling of internalized receptors.
Cellular Localization Membrane; Single-pass type I membrane protein.; Isoform 3: Secreted.
Tissue Specificity Expressed in normal hepatocytes as well as in epithelial cells lining the stomach, the small and the large intestine. Found also in basal keratinocytes of esophagus and skin. High levels are found in liver, gastrointestinal tract, thyroid and kidney. Also
Sequence and Domain Family The kinase domain is involved in SPSB1 binding.; The beta-propeller Sema domain mediates binding to HGF.


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