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Anti-Mfn2 antibody

[STJ94105] Download PDF Print Data Sheet
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Product name Anti-Mfn2 antibody
Short Description Rabbit polyclonal to Mfn2.
Description Mfn2 is a protein encoded by the MFN2 gene which is approximately 86,4 kDa. Mfn2 is localised to the mitochondrion outer membrane. It is involved in pink/parkin mediated mitophagy, toll-like receptor signalling pathways and glucose / energy metabolism. It is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. Mfn2 is ubiquitously expressed at low levels. Mutations in the MFN2 gene may result in Charcot-Marie-Tooth disease. STJ94105 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Mfn2 protein.
Applications ELISA, IHC-p, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:40000
Specificity Mfn2 Polyclonal Antibody detects endogenous levels of Mfn2 protein.
Protein Name Mitofusin-2
Transmembrane GTPase MFN2
Immunogen Synthesized peptide derived from human Mfn2.
Immunogen Region Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Rat, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 9927
Gene Symbol MFN2
Molecular Weight 86 kDa
Database Links HGNC:16877
OMIM:601152
Alternative Names Anti-Mfn2 antibody
Function Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events . Overexpression induces the formation of mitochondrial networks . Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes . Plays an important role in the regulation of vascular smooth muscle cell proliferation . Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) . Is required for PRKN recruitment to dysfunctional mitochondria . Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress . Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions .
Post-translational Modifications Phosphorylated by PINK1. Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion.
Cellular Localization Mitochondrion outer membrane. Colocalizes with BAX during apoptosis.
Tissue Specificity Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Sequence and Domain Family A helix bundle is formed by helices from the N-terminal and the C-terminal part of the protein. The GTPase domain cannot be expressed by itself, without the helix bundle. Rearrangement of the helix bundle and/or of the coiled coil domains may bring membranes from adjacent mitochondria into close contact, and thereby play a role in mitochondrial fusion.
Swiss-Prot Key O95140_HUMAN
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