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Anti-Mfn2 antibody

[STJ94105] Download PDF Print Data Sheet

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Product name Anti-Mfn2 antibody
Short Description Rabbit Polyclonal to Mfn2.
Description Mfn2 is a protein encoded by the MFN2 gene which is approximately 86,4 kDa. Mfn2 is localised to the mitochondrion outer membrane. It is involved in pink/parkin mediated mitophagy, toll-like receptor signalling pathways and glucose / energy metabolism. It is a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. Mfn2 is ubiquitously expressed at low levels. Mutations in the MFN2 gene may result in Charcot-Marie-Tooth disease. STJ94105 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Mfn2 protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:40000 /
Specificity Mfn2 Polyclonal Antibody detects endogenous levels of Mfn2 protein.
Protein Name Mitofusin-2 - MFN2 - CPRP1 - KIAA0214 - MARF - CMT2A2 - mitofusin 2
Immunogen Synthesized peptide derived from human Mfn2.
Immunogen Region Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 9927 (Human) / 170731 (Mouse) /
Gene Symbol MFN2
Molecular Weight 86 kDa
Database Links Human UniProt/Swiss-Prot:O95140 Mouse UniPort/Swiss-Prot: Q80U63 Rat UniProt/Swiss-Port: Q6IRL2 Human Entrez Gene: 9927 Mouse Entrez Gene: 170731 Rat Entrez Gene: Rn.8570
Alternative Names MFN2 / mitofusin 2 / A306_13109 antibody / AS27_12973 antibody / AS28_08745 antibody / CMT2A antibody / CMT2A2 antibody / cprp1 antibody / D623_10022029 antibody / EGK_00242 antibody / Fzo antibody / H920_06997 antibody / HMSN6A antibody / HSG antibody / HSG protein antibody / hyperplasia suppressor antibody / hypertension-related protein antibody / hypertension related protein 1 antibody / hypertension-related protein 1 antibody / hypothetical protein antibody / M91_08661 antibody / M959_03291 antibody / marf antibody / MDA_GLEAN10024361 antibody / mitochondrial assembly regulatory factor antibody / mitochondrial transmembrane GTPase FZO1A antibody / Mitofusin-2 antibody / mitofusin-2-like protein antibody / N300_01441 antibody / N301_11334 antibody / N303_02600 antibody / N305_00873 antibody / N306_05313 antibody / N307_01426 antibody / N309_10641 antibody / N310_08596 antibody / N312_10337 antibody / N320_10248 antibody / N321_07709 antibody / N322_08426 antibody / N324_05412 antibody / N325_08848 antibody / N326_11556 antibody / N327_13920 antibody / N328_07347 antibody / N329_10131 antibody / N330_00238 antibody / N331_09791 antibody / N332_13130 antibody / N333_08407 antibody / N335_12202 antibody / N336_11350 antibody / N340_11767 antibody / N341_07747 antibody / PAL_GLEAN10012982 antibody / PANDA_011824 antibody / transmembrane GTPase MFN2 antibody / UY3_01219 antibody / Y1Q_007806 antibody / Y956_10753 antibody / Z169_14429 antibody
Function Mitochondrial outer membrane GTPase that mediates mitochondrial clustering and fusion . Mitochondria are highly dynamic organelles, and their morphology is determined by the equilibrium between mitochondrial fusion and fission events . Overexpression induces the formation of mitochondrial networks . Membrane clustering requires GTPase activity and may involve a major rearrangement of the coiled coil domains (Probable). Plays a central role in mitochondrial metabolism and may be associated with obesity and/or apoptosis processes (By similarity). Plays an important role in the regulation of vascular smooth muscle cell proliferation (By similarity). Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) . Is required for PRKN recruitment to dysfunctional mitochondria . Involved in the control of unfolded protein response (UPR) upon ER stress including activation of apoptosis and autophagy during ER stress (By similarity). Acts as an upstream regulator of EIF2AK3 and suppresses EIF2AK3 activation under basal conditions (By similarity).
Post-translational Modifications Phosphorylated by PINK1. ; Ubiquitinated by non-degradative ubiquitin by PRKN, promoting mitochondrial fusion; deubiquitination by USP30 inhibits mitochondrial fusion.
Cellular Localization Mitochondrion outer membrane Note=Colocalizes with BAX during apoptosis.
Tissue Specificity Ubiquitous; expressed at low level. Highly expressed in heart and kidney.
Sequence and Domain Family A helix bundle is formed by helices from the N-terminal and the C-terminal part of the protein. The GTPase domain cannot be expressed by itself, without the helix bundle. Rearrangement of the helix bundle and/or of the coiled coil domains may bring membranes from adjacent mitochondria into close contact, and thereby play a role in mitochondrial fusion.

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