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Anti-Myotubularin antibody

[STJ94317] Download PDF Print Data Sheet
5-7 days

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Product name Anti-Myotubularin antibody
Short Description Rabbit polyclonal to Myotubularin.
Description Myotubularin is a protein encoded by the MTM1 gene which is approximately 69,9 kDa. Myotubularin is localised to the cytoplasm and cell membrane. It is involved in PI metabolism, inositol phosphate metabolism and glycerophospholipid biosynthesis. It negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. It also plays a role in mitochondrial morphology and positioning and is required for skeletal muscle maintenance. Myotubularin is expressed in the blood, nervous system and muscle. Mutations in the MTM1 gene may result in X-linked myopathy and Charcot-Marie-tooth disease. STJ94317 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Myotubularin protein.
Applications ELISA, WB
Dilution range WB 1:500-1:2000
ELISA 1:10000
Specificity Myotubularin Polyclonal Antibody detects endogenous levels of Myotubularin protein.
Protein Name Myotubularin
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase
Phosphatidylinositol-3-phosphate phosphatase
Immunogen Synthesized peptide derived from human Myotubularin.
Immunogen Region Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Mouse, Human
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 4534
Gene Symbol MTM1
Molecular Weight 70 kDa
Database Links HGNC:7448
OMIM:300415
Alternative Names Anti-Myotubularin antibody
Function Lipid phosphatase which dephosphorylates phosphatidylinositol 3-monophosphate (PI3P) and phosphatidylinositol 3,5-bisphosphate (PI(3,5)P2). Has also been shown to dephosphorylate phosphotyrosine- and phosphoserine-containing peptides. Negatively regulates EGFR degradation through regulation of EGFR trafficking from the late endosome to the lysosome. Plays a role in vacuolar formation and morphology. Regulates desmin intermediate filament assembly and architecture. Plays a role in mitochondrial morphology and positioning. Required for skeletal muscle maintenance but not for myogenesis.
Cellular Localization Cytoplasm Cell membrane; Peripheral membrane protein Cell projection, filopodium Cell projection, ruffle Late endosome. Localizes as a dense cytoplasmic network. Also localizes to the plasma membrane, including plasma membrane extensions such as filopodia and ruffles. Predominantly located in the cytoplasm following interaction with MTMR12. Recruited to the late endosome following EGF stimulation.
Sequence and Domain Family The GRAM domain mediates binding to PI(3,5)P2 and, with lower affinity, to other phosphoinositides.
Swiss-Prot Key Q13496_HUMAN
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