SHOPPING BASKET: 0 item(s) - £0.00  

You have no items in your shopping cart.

Anti-Neu antibody

[STJ94412] Download PDF Print Data Sheet

* Required Fields

£0.00
Product name Anti-Neu antibody
Short Description Rabbit Polyclonal to Neu.
Description Neu is a protein encoded by the ERBB2 gene which is approximately 137,9 kDa. Neu isoform 1 is localised to the cell membrane and isoform 2 and 3 are localised to the nucleus and cytoplasm. It is involved in RET signalling, the GPCR pathway, signalling by ERBB2 and glioma. It is a protein tyrosine kinase that is part of several cell surface receptor complexes. It has no ligand binding domain of its own and therefore cannot bind growth factors. It however does bind to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways. Neu is expressed in a variety of tumor tissues including primary breast tumors. Mutations in the ERBB2 gene may result in lung cancer and ovarian cancer. STJ94412 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of Neu protein.
Applications IHC-p, ELISA, IF, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:20000 /
Specificity Neu Polyclonal Antibody detects endogenous levels of Neu protein.
Protein Name Receptor tyrosine-protein kinase erbB-2 - ERBB2 - NEU - HER-2 - CD340 - HER2 - NGL - erb-b2 receptor tyrosine kinase 2
Immunogen Synthesized peptide derived from human Neu
Immunogen Region 610-690 aa, Internal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 2064 (Human) / 13866 (Mouse) /
Gene Symbol ERBB2
Molecular Weight 138 kDa
Database Links Human UniProt/Swiss-Prot:P04626 Mouse UniPort/Swiss-Prot: P70424 Rat UniProt/Swiss-Port: Q8K3F9 Human Entrez Gene: 2064 Mouse Entrez Gene: 13866 Rat Entrez Gene: Rn.93966
Alternative Names ERBB2 / erb-b2 receptor tyrosine kinase 2 / A306_14842 antibody / avian erythroblastosis oncogene B 2 antibody / Avian erythroblastosis viral (v-erb-B2) oncogene homologue 2 (neuro /glioblastoma derived oncogene homolog) antibody / CB1_000261013 antibody / CD340 antibody / c-erbB2 antibody / c-erbB-2 antibody / c-erb B2 /neu protein antibody / c-neu antibody / epidermal growth factor receptor-related protein antibody / epidermal growth factor receptor type 2 antibody / erb2 antibody / Erbb-2 antibody / erythroblastic leukemia viral oncogene-like 2 antibody / H920_03593 antibody / HER2 antibody / HER-2 antibody / HER-2 /neu antibody / herstatin antibody / human epidermal growth factor receptor 2 antibody / hypothetical protein antibody / l11Jus8 antibody / metastatic lymph node gene 19 protein antibody / MLN 19 antibody / N300_06111 antibody / N303_15443 antibody / Neu antibody / Neu oncogene antibody / NEU proto-oncogene antibody / neuroblastoma /glioblastoma derived oncogene homolog antibody / neuro /glioblastoma derived oncogene homolog antibody / NGL antibody / p-185 antibody / p185erbB2 antibody / p185neu antibody / PAL_GLEAN10019615 antibody / PANDA_019575 antibody / proto-oncogene c-ErbB-2 antibody / proto-oncogene Neu antibody / receptor tyrosine kinase ErbB2 antibody / receptor tyrosine-protein kinase erbB-2 antibody / TKR1 antibody / TREES_T100004473 antibody / tyrosine kinase-type cell surface receptor HER2 antibody / UY3_09125 antibody / v-erb-b2 avian erythroblastic leukemia viral oncogene 2 antibody / v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody / v-erb-b2 avian erythroblastic leukemia viral oncogene-like protein 2 antibody / v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2 antibody / v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 / neuro /glioblastoma derived oncogene homolog antibody / v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 / neuro /glioblastoma derived oncogene homolog (avian) antibody / v-erb-b2 erythroblastic leukemia viral oncoprotein-like protein 2 antibody / XerbB2 antibody / Y1Q_006200 antibody / Y956_03410 antibody
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. ; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Post-translational Modifications Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues . Signaling via SEMA4C promotes phosphorylation at Tyr-1248 . Dephosphorylated by PTPN12 .
Cellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Tags:

Use spaces to separate tags. Use single quotes (') for phrases.

Bad Good
Enter the code in the box below: