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Anti-Neu antibody

[STJ94416] Download PDF Print Data Sheet

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Product name Anti-Neu antibody
Description Rabbit Polyclonal to Neu.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000
IHC 1:100-1:300
ELISA 1:5000
Specificity Neu Polyclonal Antibody detects endogenous levels of Neu protein.
Protein Name Receptor tyrosine-protein kinase erbB-2
Metastatic lymph node gene 19 protein
MLN 19
Proto-oncogene Neu
Proto-oncogene c-ErbB-2
Tyrosine kinase-type cell surface receptor HER2
p185erbB2
CD antigen CD340
Immunogen Synthesized peptide derived from human Neu around the non-phosphorylation site of Y1248.
Immunogen Region 1180-1260 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 2064
Gene Symbol ERBB2
Molecular Weight 150 kDa
Database Links HGNC:3430
OMIM:137800
Alternative Names ERBB2 antibody
HER2 antibody
MLN19 antibody
NEU antibody
NGL antibody
Receptor tyrosine-protein kinase erbB-2 antibody
Metastatic lymph node gene 19 protein antibody
MLN 19 antibody
Proto-oncogene Neu antibody
Proto-oncogene c-ErbB-2 antibody
Tyrosine kinase-type cell surface receptor HER2 antibody
p185erbB2 antibody
CD antigen CD340 antibody
Function Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization. ; In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.
Post-translational Modifications Autophosphorylated. Autophosphorylation occurs in trans, i.e. one subunit of the dimeric receptor phosphorylates tyrosine residues on the other subunit (Probable). Ligand-binding increases phosphorylation on tyrosine residues . Signaling via SEMA4C promotes phosphorylation at Tyr-1248 . Dephosphorylated by PTPN12 .
Cellular Localization Isoform 1: Cell membrane; Single-pass type I membrane protein. Cytoplasm, perinuclear region. Nucleus. Note=Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1.; Isoform 2: Cytoplasm. Nucleus.; Isoform 3: Cytoplasm. Nucleus.
Tissue Specificity Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

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