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Anti-NPAS4 antibody

[STJ94544] Download PDF Print Data Sheet

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Product name Anti-NPAS4 antibody
Short Description Rabbit Polyclonal to NPAS4.
Description Rabbit Polyclonal to NPAS4.
Applications IHC-p, ELISA
Dilution range IHC 1:100-1:300 / ELISA 1:20000 /
Specificity NPAS4 Polyclonal Antibody detects endogenous levels of NPAS4 protein.
Protein Name Neuronal PAS domain-containing protein 4 - NPAS4 - PASD10 - NXF - Le-PAS - bHLHe79 - neuronal PAS domain protein 4
Immunogen Synthesized peptide derived from human NPAS4
Immunogen Region 580-660 aa, C-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 266743 (Human) / 225872 (Mouse) / 266734 (Rat)
Gene Symbol NPAS4
Molecular Weight 87.117 kDa
Database Links Human UniProt/Swiss-Prot:Q8IUM7 Mouse UniPort/Swiss-Prot: Q8BGD7 Rat UniProt/Swiss-Port: Q8CJH6 Human Entrez Gene: 266743 Mouse Entrez Gene: 225872 Rat Entrez Gene: Rn.86654
Alternative Names NPAS4 / BHLHE79 / NXF / PASD10 / Neuronal PAS domain-containing protein 4 / Neuronal PAS4 / Class E basic helix-loop-helix protein 79 / bHLHe79 / HLH-PAS transcription factor NXF / PAS domain-containing protein 10
Function Transcription factor expressed in neurons of the brain that regulates the excitatory-inhibitory balance within neural circuits and is required for contextual memory in the hyppocampus (By similarity). Plays a key role in the structural and functional plasticity of neurons (By similarity). Acts as an early-response transcription factor in both excitatory and inhibitory neurons, where it induces distinct but overlapping sets of late-response genes in these two types of neurons, allowing the synapses that form on inhibitory and excitatory neurons to be modified by neuronal activity in a manner specific to their function within a circuit, thereby facilitating appropriate circuit responses to sensory experience (By similarity). In excitatory neurons, activates transcription of BDNF, which in turn controls the number of GABA-releasing synapses that form on excitatory neurons, thereby promoting an increased number of inhibitory synapses on excitatory neurons (By similarity). In inhibitory neurons, regulates a distinct set of target genes that serve to increase excitatory input onto somatostatin neurons, probably resulting in enhanced feedback inhibition within cortical circuits (By similarity). The excitatory and inhibitory balance in neurons affects a number of processes, such as short-term and long-term memory, acquisition of experience, fear memory, response to stress and social behavior (By similarity). Acts as a regulator of dendritic spine development in olfactory bulb granule cells in a sensory-experience-dependent manner by regulating expression of MDM2 (By similarity). Efficient DNA binding requires dimerization with another bHLH protein, such as ARNT, ARNT2 or BMAL1 . Can activate the CME (CNS midline enhancer) element .
Post-translational Modifications Ubiquitinated, leading to degradation by the proteosome.
Cellular Localization Nucleus
Tissue Specificity Brain.

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