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Anti-NT-3 antibody

[STJ98718] Download PDF Print Data Sheet

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Product name Anti-NT-3 antibody
Short Description Rabbit Polyclonal to NT-3.
Description NT-3 is a protein encoded by the NTF3 gene which is approximately 29,4 kDa. NT-3 is secreted and is involved in apoptotic pathways in synovial fibroblasts, the GPCR pathway, ERK signalling, TGF-beta pathway and nanog in mammalian ESC pluripotency. This protein falls under the neurotrophin family. It controls survival and differentiation of mammalian neurons and is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo. NT-3 is expressed in the brain and peripheral tissues. Mutations in the NTF3 gene result in diabetic neuropathy and pediatric fibrosarcoma. STJ98718 was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. This polyclonal antibody binds to endogenous NT-3.
Applications IHC-p, ELISA, ICC
Dilution range IHC-P 1:50-300 / ELISA 1:5000-20000
Specificity The antibody detects endogenous NT-3.
Protein Name NTF3 - Neurotrophin-3 precursor - NTF3 - NGF2 - neurotrophin 3
Immunogen Synthetic peptide from human NT-3 protein.
Immunogen Region 180-230 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Isotype IgG
Formulation PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
Gene ID 4908 (Human)
Gene Symbol NTF3
Database Links Human Uniprot-Swiss-Prot: P20783 Human Entrez Gene: 4908. Mouse Uniprot/Swiss-prot:P20181 Mouse Entrez Gene:P20181 Rat Uniprot/Swiss-Prot:P18280 Rat Entrez Gene:81737
Alternative Names NTF3 / neurotrophin 3 / A306_10010 antibody / AS27_14177 antibody / AS28_13005 antibody / CB1_000216028 antibody / D623_10008272 antibody / EGK_03263 antibody / GW7_12093 antibody / H920_18357 antibody / hdnf antibody / M91_18459 antibody / M959_09793 antibody / MDA_GLEAN10016065 antibody / N300_02604 antibody / N301_01233 antibody / N302_08671 antibody / N303_06044 antibody / N305_07552 antibody / N306_14454 antibody / N307_11804 antibody / N309_04442 antibody / N310_01626 antibody / N311_02882 antibody / N312_01435 antibody / N320_07974 antibody / N321_13507 antibody / N324_03527 antibody / N325_10129 antibody / N327_13735 antibody / N328_09596 antibody / N329_12688 antibody / N330_07525 antibody / N331_11776 antibody / N332_13631 antibody / N333_09858 antibody / N334_13480 antibody / N335_12178 antibody / N336_05162 antibody / N339_07324 antibody / N341_12136 antibody / nerve growth factor 2 antibody / neurotrophic factor antibody / neurotrophin-3 antibody / neurotrophin-3 (HDNF /NT-3) antibody / neurotrophin-3 isoform 1 preproprotein antibody / ngf2 antibody / ngf-2 antibody / nt-3 antibody / NT3 antibody / Ntf-3 antibody / PANDA_016590 antibody / TREES_T100008251 antibody / UY3_04319 antibody / Y1Q_017453 antibody / Y956_15981 antibody / Z169_06952 antibody.
Function Seems to promote the survival of visceral and proprioceptive sensory neurons.
Cellular Localization Secreted.
Tissue Specificity Brain and peripheral tissues.

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