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Anti-p63 antibody

[STJ96548] Download PDF Print Data Sheet

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Product name Anti-p63 antibody
Short Description Rabbit Polyclonal to p63.
Description P63 is a protein encoded by the TP63 gene which is approximately 76,8 kDa. P63 is localised to the nucleus and is involved in the regulation of transcription of cell death genes, activation of BH3-only proteins, regulation of TP53 activity and gene expression. This protein falls under the p53 family of transcription factors. p63 acts as a sequence specific DNA binding transcriptional activator or repressor. By interacting with TP73/p73 it may also be required for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. It is expressed in the skin, muscle, blood and lungs. Mutations in the TP63 gene can result in ectrodactyly and Rap-Hodgkin syndrome. STJ96548 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This polyclonal antibody detects endogenous levels of p63 protein.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC-P 1:100-300 / ELISA 1:20000 /
Specificity p63 Polyclonal Antibody detects endogenous levels of p63 protein.
Protein Name Tumor protein 63 - TP63 - p51 - SHFM4 - EEC3 - p63 - p73L - OFC8 - KET - p73H - NBP - p53CP - TP73L - TP53L - TP53CP - tumor protein p63
Immunogen Synthesized peptide derived from human p63.
Immunogen Region 51-100 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 8626 (Human) / 22061 (Mouse) / 246334 (Rat)
Gene Symbol TP63
Molecular Weight 63 kDa
Database Links Human UniProt/Swiss-Prot:Q9H3D4 Mouse UniPort/Swiss-Prot: O88898 Rat UniProt/Swiss-Port: Q9JJP6 Human Entrez Gene: 8626 Mouse Entrez Gene: 22061 Rat Entrez Gene: Rn.42907
Alternative Names TP63 / tumor protein p63 / A306_13264 antibody / AIS antibody / amplified in squamous cell carcinoma antibody / AS27_10182 antibody / AS28_03387 antibody / B(p51A) antibody / B(p51B) antibody / CB1_001118032 antibody / cellular tumor antigen p53 antibody / chronic ulcerative stomatitis protein antibody / CUSP antibody / D623_10011644 antibody / delta-Np63 antibody / DNp63 antibody / EEC3 antibody / EGK_12210 antibody / fc89f04 antibody / GW7_21812 antibody / H920_05348 antibody / hypothetical protein antibody / I79_000859 antibody / keratinocyte transcription factor KET antibody / Ket antibody / LMS antibody / M91_00305 antibody / MDA_GLEAN10014158 antibody / N300_13337 antibody / N301_05167 antibody / N302_03807 antibody / N303_03012 antibody / N305_01905 antibody / N306_14128 antibody / N307_01617 antibody / N308_13857 antibody / N309_06273 antibody / N310_11497 antibody / N311_07511 antibody / N312_07684 antibody / N320_05036 antibody / N321_01659 antibody / N322_08103 antibody / N324_08455 antibody / N325_01229 antibody / N326_08375 antibody / N327_00730 antibody / N328_09988 antibody / N329_07265 antibody / N330_02786 antibody / N331_06865 antibody / N332_10079 antibody / N335_08644 antibody / N336_05884 antibody / N339_05899 antibody / N340_05855 antibody / N341_07321 antibody / NBP antibody / np63 antibody / OFC8 antibody / p40 antibody / p51 antibody / p53CP antibody / p63 antibody / p63 gamma antibody / p73H antibody / p73L antibody / PAL_GLEAN10018238 antibody / PANDA_002782 antibody / RHS antibody / SHFM4 antibody / TP53CP antibody / TP53L antibody / TP63 TA antibody / tp73l antibody / tp73l-A antibody / transformation related protein 63 antibody / transformation-related protein 63 antibody / TRP63 antibody / truncated P63 TA antibody / tumor protein 63 antibody / tumor protein 63 kDa antibody / tumor protein p53-competing protein antibody / tumor protein p63 deltaN isoform delta antibody / UY3_05166 antibody / Xp63 antibody / Y1Q_031692 antibody / Y956_07184 antibody
Function Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter.
Post-translational Modifications May be sumoylated. ; Ubiquitinated. Polyubiquitination involves WWP1 and leads to proteasomal degradation of this protein.
Cellular Localization Nucleus
Tissue Specificity Widely expressed, notably in heart, kidney, placenta, prostate, skeletal muscle, testis and thymus, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast, eye and prostate express high levels of DeltaN-type i
Sequence and Domain Family The transactivation inhibitory domain (TID) can interact with, and inhibit the activity of the N-terminal transcriptional activation domain of TA*-type isoforms.

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