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Anti-Patched antibody

[STJ94963] Download PDF Print Data Sheet

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Product name Anti-Patched antibody
Short Description Rabbit Polyclonal to Patched.
Description Rabbit Polyclonal to Patched.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:10000 /
Specificity Patched Polyclonal Antibody detects endogenous levels of Patched protein.
Protein Name Protein patched homolog 1 - PTCH1 - BCNS - NBCCS - PTCH - patched 1
Immunogen Synthesized peptide derived from human Patched
Immunogen Region 1-80 aa, N-terminal
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 5727 (Human) / 19206 (Mouse) /
Gene Symbol PTCH1
Molecular Weight 160 kDa
Database Links Human UniProt/Swiss-Prot:Q13635 Mouse UniPort/Swiss-Prot: Q61115 Rat UniProt/Swiss-Port: Q6UY90 Human Entrez Gene: 5727 Mouse Entrez Gene: 19206 Rat Entrez Gene: Rn.102312
Alternative Names PTCH1 / patched 1 / A306_05290 antibody / AS27_03032 antibody / AS28_10987 antibody / BCNS antibody / CB1_000978027 antibody / D623_10015805 antibody / FANCC antibody / Fanconi anemia / complementation group C antibody / H920_10336 antibody / HPE7 antibody / hypothetical protein antibody / lep antibody / leprechaun antibody / M91_06915 antibody / M959_06076 antibody / MDA_GLEAN10009030 antibody / mes antibody / mesenchymal dysplasia antibody / N300_12321 antibody / N301_05622 antibody / N302_09752 antibody / N303_06732 antibody / N305_04463 antibody / N306_13524 antibody / N307_11198 antibody / N309_06214 antibody / N311_00707 antibody / N312_05540 antibody / N320_01331 antibody / N321_13324 antibody / N322_10179 antibody / N324_12891 antibody / N326_13077 antibody / N327_08200 antibody / N328_08000 antibody / N330_00950 antibody / N331_05967 antibody / N332_09508 antibody / N333_06682 antibody / N334_09940 antibody / N336_03653 antibody / N339_10600 antibody / N340_04841 antibody / NBCCS antibody / PAL_GLEAN10003696 antibody / PANDA_009095 antibody / patched antibody / patched1 antibody / patched-1 antibody / patched 1-like protein antibody / patched 2 antibody / patched homolog 1 antibody / patched homolog 2 antibody / patched-like protein antibody / patched protein antibody / patched protein-like protein antibody / Protein patched 1 antibody / protein patched homolog 1 antibody / Protein patched-like 1 antibody / Protein patched like protein 1 antibody / Protein patched-like protein 1 antibody / PTC antibody / ptc1 antibody / Ptc-1 antibody / ptc2 antibody / Ptch antibody / PTCH11 antibody / Ptch1 protein +12b antibody / Ptch2 antibody / PTCH protein -10 antibody / PTCH protein +12b antibody / PTCH protein -3 / 4 / 5 antibody / PTCH protein +4' / antibody / TREES_T100011277 antibody / UY3_03444 antibody / XPtc1 antibody / Y956_11784 antibody / Z169_07404 antibody
Function Acts as a receptor for sonic hedgehog (SHH), indian hedgehog (IHH) and desert hedgehog (DHH). Associates with the smoothened protein (SMO) to transduce the hedgehog's proteins signal. Seems to have a tumor suppressor function, as inactivation of this protein is probably a necessary, if not sufficient step for tumorigenesis.
Post-translational Modifications Glycosylation is necessary for SHH binding. ; In the absence of Hh ligands, ubiquitination by ITCH at Lys-1426 promotes endocytosis and both proteasomal and lysosomal degradation.
Cellular Localization Membrane; Multi-pass membrane protein.
Tissue Specificity In the adult, expressed in brain, lung, liver, heart, placenta, skeletal muscle, pancreas and kidney. Expressed in tumor cells but not in normal skin.

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