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Anti-Phospho-Cofilin (S3) antibody

[STJ90230] Download PDF Print Data Sheet

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Product name Anti-Phospho-Cofilin (S3) antibody
Short Description Rabbit Polyclonal to Phospho-Cofilin (S3).
Description Cofilin is a protein encoded by the JAK1 gene which is approximately 133,2 kDa. Cofilin is localised to the endomembrane system and is involved in RET signalling, common cytokine receptor gamma-chain family signalling pathways, Th17 cell differentiation and IL27-mediated signalling events. It phosphorylates STAT proteins and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Cofilin is expressed at higher levels in primary colon tumor than normal colon tissue. Mutations in the JAK1 gene may result in mixed lacrimal gland cancer, t-cell prolymphocytic leukemia and chilblain lupus. The antibody STJ90230 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous Cofilin protein which only binds about S3 when S3 is phosphorylated.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:10000 /
Specificity Phospho-Cofilin (S3) Polyclonal Antibody detects endogenous levels of Cofilin protein only when phosphorylated at S3.
Protein Name Cofilin-1 - JAK1 - JAK1A - JTK3 - JAK1B - Janus kinase 1
Immunogen Synthesized peptide derived from human Cofilin around the phosphorylation site of S3.
Immunogen Region 10-90 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3716 (Human) / 12631 (Mouse) / 29271 (Rat)
Gene Symbol JAK1
Molecular Weight 19 kDa
Database Links Human UniProt/Swiss-Prot:P23528 Mouse UniPort/Swiss-Prot: P18760 Rat UniProt/Swiss-Port: P45592 Human Entrez Gene: 3716 Mouse Entrez Gene: 12631 Rat Entrez Gene: Rn.11675
Alternative Names CFL1 / cofilin 1 / 18 kDa phosphoprotein antibody / ADF /cofilin antibody / CB1_000429050 antibody / CFL antibody / CFL2 antibody / cfl2l antibody / Cof antibody / COFILIN antibody / cofilin-1 antibody / cofilin-1-like protein antibody / cofilin 1 (non-muscle) antibody / cofilin 1 / non-muscle antibody / cofilin / non-muscle isoform antibody / epididymis secretory protein Li 15 antibody / H920_10257 antibody / HEL-S-15 antibody / hypothetical protein antibody / M91_15924 antibody / MDA_GLEAN10017890 antibody / muscle cofilin 2 antibody / n-cofilin antibody / p18 antibody / PAL_GLEAN10011359 antibody / PANDA_004783 antibody / TREES_T100019331 antibody / UY3_03601 antibody / xac1 antibody / xac2 antibody
Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway . Kinase partner for the interleukin (IL)-2 receptor .
Post-translational Modifications Autophosphorylated . Phosphorylated on tyrosine residues in response to interferon gamma signaling . Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling . ; Ubiquitinated by RNF125; leading to its degradation by the proteasome.
Cellular Localization Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Tissue Specificity Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Sequence and Domain Family Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1. ; The FERM domain mediates interaction with JAKMIP1.

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