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Anti-Phospho-JAK1 (Y1022) antibody

[STJ90314] Download PDF Print Data Sheet

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Product name Anti-Phospho-JAK1 (Y1022) antibody
Short Description Rabbit Polyclonal to Phospho-JAK1 (Y1022).
Description JAK1 is a protein encoded by the JAK1 gene which is approximately 133,2 kDa. JAK1 is localised to the endomembrane system. It is involved in RET signalling, Th17 cell differentiation, influenza A and IL27-mediated signalling events. It is a membrane protein that is a member of a class of protein-tyrosine kinases characterized by the presence of a second phosphotransferase-related domain at the N-terminal to the PTK domain. It plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. JAK1 is expressed in the nervous system, liver, blood, spleen and lung. Mutations in the JAK1 gene may result in chilblain lupus and T-cell prolymphocytic leukemia. STJ90314 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous JAK1 protein which only binds about Y1022 when Y1022 is phosphorylated.
Applications IHC-p, ELISA, WB
Dilution range WB 1:500-1:2000 / IHC 1:100-1:300 / ELISA 1:10000 /
Specificity Phospho-JAK1 (Y1022) Polyclonal Antibody detects endogenous levels of JAK1 protein only when phosphorylated at Y1022.
Protein Name Tyrosine-protein kinase JAK1 - JAK1 - JAK1A - JTK3 - JAK1B - Janus kinase 1
Immunogen Synthesized peptide derived from human JAK1 around the phosphorylation site of Y1022.
Immunogen Region 960-1040 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 3716 (Human) /
Gene Symbol JAK1
Molecular Weight 132 kDa
Database Links Human UniProt/Swiss-Prot:P23458 Rat UniProt/Swiss-Port: G3V9W2 Human Entrez Gene: 3716 Mouse Entrez Gene: 16451 Rat Entrez Gene: Rn.90191
Alternative Names JAK1 / Janus kinase 1 / AS27_08214 antibody / BAP004 antibody / CB1_000538006 antibody / D623_10021885 antibody / etID309794.6 antibody / fb93e10 antibody / H920_15358 antibody / hypothetical protein antibody / I79_015969 antibody / jak-1 antibody / jak1a antibody / jak1b antibody / jak1 kinase antibody / Janus kinase-1 antibody / Janus kinase 1 (a protein tyrosine kinase) antibody / Janus protein tyrosine kinase 1 antibody / JTK3 antibody / M959_04932 antibody / N300_00642 antibody / N302_07524 antibody / N305_12730 antibody / N307_09386 antibody / N308_08002 antibody / N309_10667 antibody / N311_03330 antibody / N312_02217 antibody / N320_03549 antibody / N325_12659 antibody / N326_12133 antibody / N328_12663 antibody / N330_14538 antibody / N332_12702 antibody / N333_13202 antibody / N334_01846 antibody / N335_11898 antibody / N340_14803 antibody / PAL_GLEAN10023833 antibody / protein tyrosine kinase antibody / tyrosine kinase JAK1 antibody / tyrosine-protein kinase JAK1 antibody / UY3_10453 antibody / Y1Q_027732 antibody / Y956_08805 antibody
Function Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway . Kinase partner for the interleukin (IL)-2 receptor .
Post-translational Modifications Autophosphorylated . Phosphorylated on tyrosine residues in response to interferon gamma signaling . Dephosphorylation of Tyr-1034 and Tyr-1035 by PTPN2 negatively regulates cytokine-mediated signaling . ; Ubiquitinated by RNF125; leading to its degradation by the proteasome.
Cellular Localization Endomembrane system; Peripheral membrane protein. Note=Wholly intracellular, possibly membrane associated.
Tissue Specificity Expressed at higher levels in primary colon tumors than in normal colon tissue. The expression level in metastatic colon tumors is comparable to the expression level in normal colon tissue.
Sequence and Domain Family Possesses two phosphotransferase domains. The second one probably contains the catalytic domain, while the presence of slight differences suggest a different role for domain 1. ; The FERM domain mediates interaction with JAKMIP1.

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