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Anti-Phospho-Synapsin I (S605) antibody

[STJ91309] Download PDF Print Data Sheet
Anti-Phospho-Synapsin I (S605) antibody

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Product name Anti-Phospho-Synapsin I (S605) antibody
Short Description Rabbit Polyclonal to Phospho-Synapsin I (S605).
Description Synapsin I is a protein encoded by the SYN1 gene which is approximately 74,1 kDa. Synapsin I is localised to the Golgi apparatus and cell junction. It is involved in the neurotransmitter release cycle, MAPK-Erk pathway and the brain-derived neurotrophic factor signalling pathway. It is a neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton and is believed to function in the regulation of neurotransmitter release. It forms a complex with NOS1 and CAPON proteins and is necessary for specific nitric-oxide functions at a presynaptic level. Synapsin I is expressed in the nervous system, adrenal gland and eye. Mutations in the SYN1 gene may result in X-linked epilepsy. STJ91309 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous synapsin I protein which only binds about S605 when S605 is phosphorylated.
Applications IHC-p, ELISA, IF
Dilution range IHC 1:100-1:300 / IF 1:200-1:1000 / ELISA 1:20000 /
Specificity Phospho-Synapsin I (S605) Polyclonal Antibody detects endogenous levels of Synapsin I protein only when phosphorylated at S605.
Protein Name Synapsin-1 - SYN1 - synapsin I
Immunogen Synthesized peptide derived from human Synapsin I around the phosphorylation site of S605.
Immunogen Region 550-630 aa
Storage Instruction Store at -20°C, and avoid repeat freeze-thaw cycles.
Note For Research Use Only (RUO).
Host Rabbit
Clonality Polyclonal
Reactivity Human, Mouse, Rat
Conjugation Unconjugated
Concentration 1 mg/ml
Purification The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Isotype IgG
Formulation Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Gene ID 6853 (Human) / 20964 (Mouse) / 24949 (Rat)
Gene Symbol SYN1
Molecular Weight 77 kDa
Database Links Human UniProt/Swiss-Prot:P17600 Mouse UniPort/Swiss-Prot: O88935 Rat UniProt/Swiss-Port: P09951 Human Entrez Gene: 6853 Mouse Entrez Gene: 20964 Rat Entrez Gene: Rn.9923
Alternative Names SYN1 / synapsin I / brain protein 4.1 antibody / CB1_001592008 antibody / CG7152-PB antibody / CG7152-PC antibody / CG7152-PD antibody / CG7152-PE antibody / D623_10006080 antibody / Dmel_CG7152 antibody / DmSYN-1 antibody / GB13525 antibody / H920_15974 antibody / hypothetical protein antibody / I79_020989 antibody / M91_07849 antibody / MDA_GLEAN10002780 antibody / PAL_GLEAN10003165 antibody / properdin antibody / Syn-1 antibody / SYN1a antibody / SYN1b antibody / Syn1-PB antibody / Syn1-PC antibody / Syn1-PD antibody / Syn1-PE antibody / Syn1-S antibody / synapsin antibody / synapsin 1 antibody / Synapsin-1 antibody / SYNI antibody / syntrophin antibody / syntrophin-like 1 antibody / TREES_T100012605 antibody / truncated synapsin 1-S antibody / Y1Q_007184 antibody
Function Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. The complex formed with NOS1 and CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Post-translational Modifications Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role in the regulation of synapsin-1 in the nerve terminal.; Phosphorylation at Ser-9 dissociates synapsins from synaptic vesicles.
Cellular Localization Cell junction, synapse. Golgi apparatus
Sequence and Domain Family The A region binds phospholipids with a preference for negatively charged species.

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